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Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex

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Title: Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex
Authors: Knopfel, T
Sweeney, Y
Radulescu, CI
Zabouri, N
Doostdar, N
Clopath, C
Barnes, S
Item Type: Journal Article
Abstract: We experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.
Issue Date: 12-Dec-2019
Date of Acceptance: 7-Nov-2019
URI: http://hdl.handle.net/10044/1/75223
DOI: 10.1038/s41467-019-13607-2
ISSN: 2041-1723
Publisher: Nature Research (part of Springer Nature)
Journal / Book Title: Nature Communications
Volume: 10
Copyright Statement: © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Sponsor/Funder: Safra Foundation
UK DRI Ltd
Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Simons Foundation
Funder's Grant Number: Edmond and Lilly Safra Scholarship
4050641385
200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Award ID:564408
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
DEPENDENT PLASTICITY
RECOGNITION MEMORY
RECEPTIVE-FIELDS
LONG-TERM
INTEGRATION
SPECIFICITY
INHIBITION
INFORMATION
MODULATION
DYNAMICS
Acoustic Stimulation
Animals
Auditory Cortex
Auditory Perception
Mice
Models, Animal
Models, Biological
Nerve Net
Neuronal Plasticity
Neurons
Photic Stimulation
Sensory Deprivation
Visual Cortex
Visual Perception
Visual Cortex
Auditory Cortex
Nerve Net
Neurons
Animals
Mice
Acoustic Stimulation
Models, Animal
Photic Stimulation
Auditory Perception
Sensory Deprivation
Visual Perception
Neuronal Plasticity
Models, Biological
Publication Status: Published
Article Number: 5684
Online Publication Date: 2019-12-12
Appears in Collections:Bioengineering
Faculty of Medicine
Department of Brain Sciences
Faculty of Engineering