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Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex
File | Description | Size | Format | |
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AudioVisualExperienceStrengthensMultisensory.pdf | Published version | 1.97 MB | Adobe PDF | View/Open |
Title: | Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex |
Authors: | Knopfel, T Sweeney, Y Radulescu, CI Zabouri, N Doostdar, N Clopath, C Barnes, S |
Item Type: | Journal Article |
Abstract: | We experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network. |
Issue Date: | 12-Dec-2019 |
Date of Acceptance: | 7-Nov-2019 |
URI: | http://hdl.handle.net/10044/1/75223 |
DOI: | 10.1038/s41467-019-13607-2 |
ISSN: | 2041-1723 |
Publisher: | Nature Research (part of Springer Nature) |
Journal / Book Title: | Nature Communications |
Volume: | 10 |
Copyright Statement: | © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
Sponsor/Funder: | Safra Foundation UK DRI Ltd Wellcome Trust Biotechnology and Biological Sciences Research Council (BBSRC) Biotechnology and Biological Sciences Research Cou Simons Foundation |
Funder's Grant Number: | Edmond and Lilly Safra Scholarship 4050641385 200790/Z/16/Z BB/P018785/1 ORCA 64155 (BB/N013956/1) Award ID:564408 |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics DEPENDENT PLASTICITY RECOGNITION MEMORY RECEPTIVE-FIELDS LONG-TERM INTEGRATION SPECIFICITY INHIBITION INFORMATION MODULATION DYNAMICS Acoustic Stimulation Animals Auditory Cortex Auditory Perception Mice Models, Animal Models, Biological Nerve Net Neuronal Plasticity Neurons Photic Stimulation Sensory Deprivation Visual Cortex Visual Perception Visual Cortex Auditory Cortex Nerve Net Neurons Animals Mice Acoustic Stimulation Models, Animal Photic Stimulation Auditory Perception Sensory Deprivation Visual Perception Neuronal Plasticity Models, Biological |
Publication Status: | Published |
Article Number: | 5684 |
Online Publication Date: | 2019-12-12 |
Appears in Collections: | Bioengineering Faculty of Medicine Department of Brain Sciences Faculty of Engineering |