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Engineering swollen cubosomes using cholesterol and anionic lipids

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Title: Engineering swollen cubosomes using cholesterol and anionic lipids
Authors: Barriga, H
Ces, O
Law, R
Seddon, J
Brooks, N
Item Type: Journal Article
Abstract: Dispersions of non-lamellar lipid membrane assemblies are gaining increasing interest for drug delivery and protein therapeutic application. A key bottleneck has been the lack of rational design rules for these systems linking different lipid species and conditions to defined lattice parameters and structures. We have developed robust methods to form cubosomes (nanoparticles with a porous internal structure) with water channel diameters of up to 171 Å which are over 4 times larger than archetypal cubosome structures. The water channel diameter can be tuned via the incorporation of cholesterol and the charged lipids DOPA, DOPG or DOPS. We have found that large molecules can be incorporated into the porous cubosome structure and these molecules can interact with the internal cubosome membrane. This offers huge potential for accessible encapsulation and protection of biomolecules, and development of confined interfacial reaction environments.
Issue Date: 17-Dec-2019
Date of Acceptance: 7-Nov-2019
URI: http://hdl.handle.net/10044/1/75221
DOI: 10.1021/acs.langmuir.9b02336
ISSN: 0743-7463
Publisher: American Chemical Society
Start Page: 16521
End Page: 16527
Journal / Book Title: Langmuir: the ACS journal of surfaces and colloids
Volume: 35
Issue: 50
Copyright Statement: © 2019 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.langmuir.9b02336
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/J017566/1
Keywords: Chemical Physics
Publication Status: Published
Online Publication Date: 2019-11-08
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences