A miniature neural recording device to investigate sleep and temperature regulation in mice

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Title: A miniature neural recording device to investigate sleep and temperature regulation in mice
Authors: Hsieh, B
Harding, E
Wisden, W
Franks, N
Constandinou, T
Item Type: Conference Paper
Abstract: Sleep is an important and ubiquitous process that,despite decades of research, a large part of its underlyingbiological circuity still remain elusive. To conduct research inthis field, many devices capable of recording neural signalssuch as LFP and EEG have been developed. However, most ofthese devices are unsuitable for sleep studies in mice, the mostcommonly used animals, due to their size and weight. Thus, thispaper presents a novel 4 channel, compact ( 2.1cm by 1.7cm )and lightweight ( 3.6g ) neural-logging device that can recordfor 3 days on just two 0.6g zinc air 312 batteries. Instead ofthe typical solution of using multiple platforms, the presenteddevice integrates high resolution EEG, EMG and temperaturerecordings into one platform. The onboard BLE module allowsthe device to be controlled wirelessly as well as stream data in realtime, enabling researchers to check the progress of the recordingwith minimal animal disturbance. The device demonstrates itsability to accurately record EEG and temperature data throughthe long 24 hour in-vivo recordings conducted. The obtainedEEG data could be easily sleep scored and the temperaturesvalues were all within expected physiological range.
Issue Date: 17-Oct-2019
Date of Acceptance: 12-Aug-2019
URI: http://hdl.handle.net/10044/1/74992
Publisher: IEEE
Copyright Statement: This paper is embargoed until publication.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (E
Funder's Grant Number: EP/M020975/1
EP/R511547/1
Conference Name: IEEE Biomedical Circuits and Systems (BioCAS) Conference
Publication Status: Accepted
Start Date: 2019-10-17
Finish Date: 2019-10-19
Conference Place: Nara, Japan
Embargo Date: publication subject to indefinite embargo
Appears in Collections:Electrical and Electronic Engineering
Faculty of Natural Sciences



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