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Differences in nasal IgA responses to influenza vaccine strains after Live Attenuated Influenza Vaccine (LAIV) immunisation in children

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Title: Differences in nasal IgA responses to influenza vaccine strains after Live Attenuated Influenza Vaccine (LAIV) immunisation in children
Authors: Turner, P
Abdulla, AF
Cole, M
Javan, RR
Gould, V
O'Driscoll, ME
Southern, J
Zambon, M
Miller, E
Andrews, NJ
Hoschler, K
Tregoning, J
Item Type: Journal Article
Abstract: Different vaccine strains included in the Live Attenuated Influenza Vaccine (LAIV) have variable efficacy. The reasons for this are not clear and may include differences in immunogenicity. We report a phase IV open‐label study on the immunogenicity of a single dose of quadrivalent LAIV (Fluenz™ Tetra) in children during the 2015/16 season, to investigate the antibody responses to different strains. Eligible children were enrolled to receive LAIV; nasal samples were collected before and approximately 4 weeks after immunisation. There was a significant increase in nasal IgA to the H3N2, B/Victoria lineage (B/Brisbane) and B/Yamagata lineage (B/Phuket) components, but not to the H1N1 component. The fold change in nasal IgA response was inversely proportional to the baseline nasal IgA titre for H1N1, H3N2 and B/Brisbane. We investigated possible associations that may explain baseline nasal IgA, including age and prior vaccination status, but found different patterns for different antigens, suggesting the response is multi‐factorial. Overall, we observed differences in immune responses to different viral strains included in the vaccine, the reasons for this require further investigation.
Issue Date: 31-Oct-2019
Date of Acceptance: 24-Oct-2019
URI: http://hdl.handle.net/10044/1/74679
DOI: 10.1111/cei.13395
ISSN: 0009-9104
Publisher: Wiley
Journal / Book Title: Clinical and Experimental Immunology
Copyright Statement: This article is protected by copyright. All rights reserved. This article will be available open access.
Sponsor/Funder: Medical Research Council (MRC)
Department of Health
Funder's Grant Number: MR/K010468/1
039/0031
Keywords: Children
Influenza
Nasal
Public Health
Vaccine
1107 Immunology
Immunology
Publication Status: Published online
Online Publication Date: 2019-10-31
Appears in Collections:National Heart and Lung Institute



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