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Standardised framework for quantitative analysisof fibrillation dynamics

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Title: Standardised framework for quantitative analysisof fibrillation dynamics
Authors: Li, X
Roney, C
Handa, B
Chowdhury, R
Niederer, S
Peters, N
Ng, FS
Item Type: Journal Article
Abstract: The analysis of complex mechanisms underlying ventricular fibrillation (VF) and atrial fibrillation (AF) requires sophisticatedtools for studying spatio-temporal action potential (AP) propagation dynamics. However, fibrillation analysis tools are oftencustom-made or proprietary, and vary between research groups. With no optimal standardised framework for analysis, resultsfrom different studies have led to disparate findings. Given the technical gap, here we present a comprehensive framework andset of principles for quantifying properties of wavefront dynamics in phase-processed data recorded during myocardial fibrillationwith potentiometric dyes. Phase transformation of the fibrillatory data is particularly useful for identifying self-perpetuating spiralwaves or rotational drivers (RDs) rotating around a phase singularity (PS). RDs have been implicated in sustaining fibrillation,and thus accurate localisation and quantification of RDs is crucial for understanding specific fibrillatory mechanisms. In thiswork, we assess how variation of analysis parameters and thresholds in the tracking of PSs and quantification of RDs couldresult in different interpretations of the underlying fibrillation mechanism. These techniques have been described and appliedto experimental AF and VF data, and AF simulations, and examples are provided from each of these data sets to demonstratethe range of fibrillatory behaviours and adaptability of these tools. The presented methodologies are available as an opensource software and offer an off-the-shelf research toolkit for quantifying and analysing fibrillatory mechanisms.
Issue Date: 13-Nov-2019
Date of Acceptance: 23-Oct-2019
URI: http://hdl.handle.net/10044/1/74651
DOI: 10.1038/s41598-019-52976-y
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 9
Copyright Statement: © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: British Heart Foundation
Rosetrees Trust
Imperial College Healthcare NHS Trust- BRC Funding
British Heart Foundation
British Heart Foundation
Rosetrees Trust
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
British Heart Foundation
British Heart Foundation
Funder's Grant Number: RG/16/3/32175
A1173/ M577
RDB02
PG/16/17/32069
PG/16/17/32069
A1407/ M645
RDB02
RDF01
RE/18/4/34215
FS/15/25/31423
Keywords: 0601 Biochemistry and Cell Biology
0299 Other Physical Sciences
Publication Status: Published
Article Number: ARTN 16671
Appears in Collections:National Heart and Lung Institute