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Surface acoustic wave enabled pipette on a chip

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Title: Surface acoustic wave enabled pipette on a chip
Authors: Sesen, M
Devendran, C
Malikides, S
Alan, T
Neild, A
Item Type: Journal Article
Abstract: Mono-disperse droplet formation in microfluidic devices allows the rapid production of thousands of identical droplets and has enabled a wide range of chemical and biological studies through repeat tests performed at pico-to-nanoliter volume samples. However, it is exactly this efficiency of production which has hindered the ability to carefully control the location and quantity of the distribution of various samples on a chip – the key requirement for replicating micro well plate based high throughput screening in vastly reduced volumetric scales. To address this need, here, we present a programmable microfluidic chip capable of pipetting samples from mobile droplets with high accuracy using a non-contact approach. Pipette on a chip (PoaCH) system selectively ejects (pipettes) part of a droplet into a customizable reaction chamber using surface acoustic waves (SAWs). Droplet pipetting is shown to range from as low as 150 pL up to 850 pL with precision down to tens of picoliters. PoaCH offers ease of integration with existing lab on a chip systems as well as a robust and contamination-free droplet manipulation technique in closed microchannels enabling potential implementation in screening and other studies.
Issue Date: 7-Feb-2017
Date of Acceptance: 14-Dec-2016
URI: http://hdl.handle.net/10044/1/74636
DOI: 10.1039/c6lc01318j
ISSN: 1473-0189
Publisher: Royal Society of Chemistry
Start Page: 438
End Page: 447
Journal / Book Title: Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering
Volume: 17
Issue: 3
Copyright Statement: © 2017 The Royal Society of Chemistry.
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Chemistry, Multidisciplinary
Chemistry, Analytical
Nanoscience & Nanotechnology
Biochemistry & Molecular Biology
Chemistry
Science & Technology - Other Topics
MICROFLUIDIC PLATFORM
MANIPULATION
CELL
GENERATION
DROPLETS
SEPARATION
SYSTEM
DRIVEN
DROPS
ARRAY
Equipment Design
Hydrodynamics
Lab-On-A-Chip Devices
Microfluidic Analytical Techniques
Models, Theoretical
Sound
Surface Properties
Microfluidic Analytical Techniques
Equipment Design
Surface Properties
Sound
Models, Theoretical
Lab-On-A-Chip Devices
Hydrodynamics
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Chemistry, Multidisciplinary
Chemistry, Analytical
Nanoscience & Nanotechnology
Biochemistry & Molecular Biology
Chemistry
Science & Technology - Other Topics
MICROFLUIDIC DEVICE
VIBRATING MEMBRANE
CAPACITIVE SENSORS
DROPLETS
MANIPULATION
CELL
GENERATION
PLATFORM
TIME
ACOUSTOPHORESIS
03 Chemical Sciences
09 Engineering
Analytical Chemistry
Publication Status: Published
Online Publication Date: 2016-12-14
Appears in Collections:Bioengineering



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