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Identifying and managing patients at risk of severe allergic reactions to food: report from two iFAAM workshops

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Title: Identifying and managing patients at risk of severe allergic reactions to food: report from two iFAAM workshops
Authors: Roberts, G
Allen, K
Ballmer-Weber, B
Clark, A
Crevel, R
Dunn Galvin, A
Fernandez-Rivas, M
Grimshaw, KEC
Hourihane, JO
Poulsen, LK
Van Ree, R
Regent, L
Remington, B
Schnadt, S
Turner, PJ
Mills, ENC
Item Type: Journal Article
Abstract: Food allergy affects a small but important number of children and adults. Much of the morbidity associated with food allergy is driven by the fear of a severe reaction, and fatalities continue to occur. Foods are the commonest cause of anaphylaxis. One of the aims of the European Union funded Integrated Approaches to Food Allergen and Allergy Risk Management (iFAAM) project was to improve the identification and management of children and adults at risk of experiencing a severe reaction. A number of interconnected studies within the project have focused on quantifying the severity of allergic reactions; the impact of food matrix, immunological factors on severity of reactions; the impact of co‐factors such as medications on the severity of reactions; utilising single dose challenges to understand threshold and severity of reactions; and community studies to understand the experience of patients suffering real‐life allergic reactions to food. Associated studies have examined population thresholds, and co‐factors such as exercise and stress. This paper summarises two workshops focused on the severity of allergic reactions to food. It outlines the related studies being undertaken in the project indicating how they are likely to impact on our ability to identify individuals at risk of severe reactions and improve their management.
Issue Date: Dec-2019
Date of Acceptance: 17-Oct-2019
URI: http://hdl.handle.net/10044/1/74525
DOI: 10.1111/cea.13516
ISSN: 0954-7894
Publisher: Wiley
Start Page: 1558
End Page: 1566
Journal / Book Title: Clinical and Experimental Allergy
Volume: 49
Issue: 12
Copyright Statement: © 2019 John Wiley & Sons Ltd. This is the accepted version of the following article: Roberts, G. , Allen, K. , Ballmer‐Weber, B. , Clark, A. , Crevel, R. , Dunn Galvin, A. , Fernandez‐Rivas, M. , Grimshaw, K. E., Hourihane, J. O., Poulsen, L. K., van Ree, R. , Regent, L. , Remington, B. , Schnadt, S. , Turner, P. J. and Mills, E. C. (2019), Identifying and managing patients at risk of severe allergic reactions to food: report from two iFAAM workshops. Clin Exp Allergy. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1111/cea.13516
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 312147
Keywords: allergy
anaphylaxis
co-factors
food
severity
Allergy
1107 Immunology
1117 Public Health and Health Services
Publication Status: Published
Embargo Date: 2020-12-12
Online Publication Date: 2019-12-12
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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