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The bio-inspired artificial pancreas for type 1 diabetes control in the home: System architecture and preliminary results

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Title: The bio-inspired artificial pancreas for type 1 diabetes control in the home: System architecture and preliminary results
Authors: Herrero, P
El-Sharkawy, M
Daniels, J
Jugnee, N
Uduku, CN
Reddy, M
Oliver, N
Georgiou, P
Item Type: Journal Article
Abstract: BACKGROUND: Artificial pancreas (AP) technology has been proven to improve glucose and patient-centered outcomes for people with type 1 diabetes (T1D). Several approaches to implement the AP have been described, clinically evaluated, and in one case, commercialized. However, none of these approaches has shown a clear superiority with respect to others. In addition, several challenges still need to be solved before achieving a fully automated AP that fulfills the users' expectations. We have introduced the Bio-inspired Artificial Pancreas (BiAP), a hybrid adaptive closed-loop control system based on beta-cell physiology and implemented directly in hardware to provide an embedded low-power solution in a dedicated handheld device. In coordination with the closed-loop controller, the BiAP system incorporates a novel adaptive bolus calculator which aims at improving postprandial glycemic control. This paper focuses on the latest developments of the BiAP system for its utilization in the home environment. METHODS: The hardware and software architectures of the BiAP system designed to be used in the home environment are described. Then, the clinical trial design proposed to evaluate the BiAP system in an ambulatory setting is introduced. Finally, preliminary results corresponding to two participants enrolled in the trial are presented. RESULTS: Apart from minor technical issues, mainly due to wireless communications between devices, the BiAP system performed well (~88% of the time in closed-loop) during the clinical trials conducted so far. Preliminary results show that the BiAP system might achieve comparable glycemic outcomes to the existing AP systems (~73% time in target range 70-180 mg/dL). CONCLUSION: The BiAP system is a viable platform to conduct ambulatory clinical trials and a potential solution for people with T1D to control their glucose control in a home environment.
Issue Date: 1-Nov-2019
Date of Acceptance: 1-Oct-2019
URI: http://hdl.handle.net/10044/1/74378
DOI: 10.1177/1932296819881456
ISSN: 1932-2968
Publisher: SAGE Publications
Start Page: 1017
End Page: 1025
Journal / Book Title: Journal of Diabetes Science and Technology
Volume: 13
Issue: 6
Copyright Statement: © 2019 SAGE. The final, definitive version of this paper has been published by Sage Publications Ltd. All rights reserved. It is available at: https://doi.org/10.1177/1932296819881456
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: WT 100921/Z/13/Z
Keywords: artificial pancreas
automatic insulin delivery
bio-inspired technology
low-power electronics
type 1 diabetes
artificial pancreas
automatic insulin delivery
bio-inspired technology
low-power electronics
type 1 diabetes
1111 Nutrition and Dietetics
Publication Status: Published
Conference Place: United States
Online Publication Date: 2019-10-14
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering
Faculty of Medicine



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