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The role of complement in IgA nephropathy

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Title: The role of complement in IgA nephropathy
Authors: Tortajada, A
Gutierrez, E
Pickering, MC
Praga Terente, M
Medjeral-Thomas, N
Item Type: Journal Article
Abstract: IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN encompasses a wide range of histology and clinical features. IgAN pathogenesis is incompletely understood; the current multi-hit hypothesis of IgAN pathogenesis does not explain the range of glomerular inflammation and renal injury associated with mesangial IgA deposition. Although associations between IgAN and glomerular and circulating markers of complement activation are established, the mechanism of complement activation and contribution to glomerular inflammation and injury are not defined. Recent identification of specific complement pathways and proteins in severe IgAN cases had advanced our understanding of complement in IgAN pathogenesis. In particular, a growing body of evidence implicates the complement factor H related proteins 1 and 5 and lectin pathway as pathogenic in a subset of patients with severe disease. These data suggest complement deregulation and activity may be dominant drivers of renal injury in IgAN. Thereby, markers of complement activation may identify IgAN patients likely to progress to significant renal impairment and complement inhibition may emerge as an effective method of preventing and reducing glomerular injury in IgAN.
Issue Date: 1-Oct-2019
Date of Acceptance: 16-Jul-2019
URI: http://hdl.handle.net/10044/1/74020
DOI: https://dx.doi.org/10.1016/j.molimm.2019.07.017
ISSN: 0161-5890
Publisher: Elsevier
Start Page: 123
End Page: 132
Journal / Book Title: Molecular Immunology
Volume: 114
Copyright Statement: © 2019 Published by Elsevier Ltd. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 212252/Z/18/Z
Keywords: Complement
Glomerulonephritis
IgA nephropathy
Complement
Glomerulonephritis
IgA nephropathy
1107 Immunology
Immunology
Publication Status: Published
Conference Place: England
Online Publication Date: 2019-07-24
Appears in Collections:Department of Immunology and Inflammation