IRUS Total

Fifteen-minute consultation: Management of the infant born to a mother with toxoplasmosis in pregnancy

File Description SizeFormat 
262.full.pdfPublished version1.31 MBAdobe PDFView/Open
Title: Fifteen-minute consultation: Management of the infant born to a mother with toxoplasmosis in pregnancy
Authors: Saso, A
Bamford, A
Grewal, K
Noori, M
Hatcher, J
D'Arco, F
Guy, E
Lyall, H
Item Type: Journal Article
Abstract: Congenital toxoplasmosis occurs following transplacental transfer of Toxoplasma gondii. Irrespective of symptom status at birth, infants with congenital infection may develop serious long-term sequelae, including learning disability, seizures, hydrocephalus, motor and hearing deficits, chorioretinitis and retinal scarring with impaired vision. Timely diagnosis facilitates early initiation of therapy, aimed at prevention or amelioration of adverse clinical consequences. Diagnosis can be difficult, however, since acutely infected mothers are often asymptomatic and laboratory testing can be complex. Moreover, any decision to start treatment in the newborn must include careful consideration of the benefits and risks. This paper outlines a structured approach for managing an infant born to a woman with possible or confirmed T. gondii infection during pregnancy, including key aspects of the antenatal history, interpretation and timing of investigations, treatment and appropriate follow-up. Our recommendations are based on current evidence in the literature, consensus from two UK paediatric infectious disease centres and the UK specialist Toxoplasma Reference Unit.
Issue Date: 1-Oct-2020
Date of Acceptance: 6-Dec-2019
URI: http://hdl.handle.net/10044/1/73327
DOI: 10.1136/archdischild-2018-316603
ISSN: 1743-0585
Publisher: BMJ Publishing Group
Start Page: 262
End Page: 269
Journal / Book Title: Archives of Disease in Childhood: Education and Practice Edition
Volume: 105
Issue: 5
Copyright Statement: © 2020 Author(s) (or their employer(s)). This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Keywords: Pediatrics
1114 Paediatrics and Reproductive Medicine
Publication Status: Published
Online Publication Date: 2020-02-18
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Faculty of Medicine

This item is licensed under a Creative Commons License Creative Commons