5
IRUS TotalDownloads
Altmetric
N-cadherin orchestrates self-organization of neurons within a columnar unit in the drosophila medulla
File | Description | Size | Format | |
---|---|---|---|---|
![]() | Accepted version | 159.42 kB | Microsoft Word | View/Open |
Title: | N-cadherin orchestrates self-organization of neurons within a columnar unit in the drosophila medulla |
Authors: | Trush, O Liu, C Han, X Nakai, Y Takayama, R Murakawa, H Carrillo, JA Takechi, H Hakeda-Suzuki, S Suzuki, T Sato, M |
Item Type: | Journal Article |
Abstract: | Columnar structure is a basic unit of the brain, but the mechanism underlying its development remains largely unknown. The medulla, the largest ganglion of the Drosophila melanogaster visual center, provides a unique opportunity to reveal the mechanisms of 3D organization of the columns. In this study, using N-cadherin (Ncad) as a marker, we reveal the donut-like columnar structures along the 2D layer in the larval medulla that evolves to form three distinct layers in pupal development. Column formation is initiated by three core neurons, R8, R7, and Mi1, which establish distinct concentric domains within a column. We demonstrate that Ncad-dependent relative adhesiveness of the core columnar neurons regulates their relative location within a column along a 2D layer in the larval medulla according to the differential adhesion hypothesis. We also propose the presence of mutual interactions among the three layers during formation of the 3D structures of the medulla columns. |
Issue Date: | 24-Jul-2019 |
Date of Acceptance: | 15-May-2019 |
URI: | http://hdl.handle.net/10044/1/73087 |
DOI: | https://doi.org/10.1523/JNEUROSCI.3107-18.2019 |
ISSN: | 0270-6474 |
Publisher: | Society for Neuroscience |
Start Page: | 5861 |
End Page: | 5880 |
Journal / Book Title: | Journal of Neuroscience |
Volume: | 39 |
Issue: | 30 |
Copyright Statement: | © 2019 the authors. |
Sponsor/Funder: | The Royal Society Engineering & Physical Science Research Council (EPSRC) |
Funder's Grant Number: | WM120001 EP/P031587/1 |
Keywords: | Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology columnar unit differential adhesion Drosophila N-cadherin optic lobe visual system VISUAL-SYSTEM DN-CADHERIN ADHESION EXPRESSION SPECIFICATION RECEPTOR AXON DIFFERENTIATION SELECTION CIRCUITS Drosophila N-cadherin columnar unit differential adhesion optic lobe visual system Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology columnar unit differential adhesion Drosophila N-cadherin optic lobe visual system VISUAL-SYSTEM DN-CADHERIN ADHESION EXPRESSION SPECIFICATION RECEPTOR AXON DIFFERENTIATION SELECTION CIRCUITS 11 Medical and Health Sciences 17 Psychology and Cognitive Sciences Neurology & Neurosurgery |
Publication Status: | Published |
Online Publication Date: | 2019-07-24 |
Appears in Collections: | Mathematics Applied Mathematics and Mathematical Physics Faculty of Natural Sciences |