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Does neutrophil phenotype predict the survival of trauma patients?

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Title: Does neutrophil phenotype predict the survival of trauma patients?
Authors: Adcock, I
Mumby, S
Item Type: Journal Article
Abstract: According to the World Health Organization (WHO), trauma is responsible for 10% of deaths and 16% of disabilities worldwide. This is considerably higher than those for malaria, tuberculosis, and HIV/AIDS combined. While the human suffering and death caused by injury is well recognized, injury has a significant medical care cost. Better prediction of the state of trauma patients in the days immediately after trauma may reduce costs. Traumatic injuries to multiple organs can cause dysfunction in all systems of the body especially the immune system placing patients at high risk of infections and inflammatory complications which are often fatal. Neutrophils are the most abundant leukocyte in the human circulation and are crucial for the prevention of microbial disease. Significant changes in neutrophil functions such as enhanced chemotaxis, Neutrophil extracellular trap (NET)-induced cell death (NETosis) and phagocytosis occur early after injury followed by prolonged functional defects such as phagocytosis, killing mechanisms, and receptor expression. Analysis of these changes may improve the prediction of the patient’s condition over time. We provide a comprehensive and up-to-date review of the literature investigating the effect of trauma on neutrophil phenotype with an underlying goal of using this knowledge to examine the predictive potential of neutrophil alterations on secondary complications in patients with traumatic injuries. We conclude that alterations in neutrophil surface markers and functions may be potential biomarkers that predict the outcome of trauma patients.
Issue Date: 6-Sep-2019
Date of Acceptance: 23-Aug-2019
URI: http://hdl.handle.net/10044/1/73031
DOI: https://doi.org/10.3389/fimmu.2019.02122
ISSN: 1664-3224
Publisher: Frontiers Media
Start Page: 1
End Page: 14
Journal / Book Title: Frontiers in Immunology
Volume: 10
Copyright Statement: © 2019 Mortaz, Zadian, Shahir, Folkerts, Garssen, Mumby and Adcock. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
British Heart Foundation
Dunhill Medical Trust
Wellcome Trust
Funder's Grant Number: 208340/Z/17/Z
EP/T003189/1
PG/14/27/30679
R368/0714
093080/Z/10/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
trauma
neutrophil subtype
injury
survival
neutrophils
INFLAMMATORY RESPONSE SYNDROME
MULTIPLE ORGAN FAILURE
SOLUBLE L-SELECTIN
COLONY-STIMULATING FACTOR
INNATE IMMUNE-RESPONSE
DNA CF-DNA/NETS
EXTRACELLULAR TRAPS
PROGNOSTIC VALUE
CD64 EXPRESSION
CELL-DEATH
injury
neutrophil subtype
neutrophils
survival
trauma
1107 Immunology
Publication Status: Published
Article Number: 2122
Online Publication Date: 2019-09-06
Appears in Collections:National Heart and Lung Institute