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Learning interpretable anatomical features through deep generative models: Application to cardiac remodeling

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Title: Learning interpretable anatomical features through deep generative models: Application to cardiac remodeling
Authors: Biffi, C
Oktay, O
Tarroni, G
Bai, W
De Marvao, A
Doumou, G
Rajchl, M
Bedair, R
Prasad, S
Cook, S
O’Regan, D
Rueckert, D
Item Type: Conference Paper
Abstract: Alterations in the geometry and function of the heart define well-established causes of cardiovascular disease. However, current approaches to the diagnosis of cardiovascular diseases often rely on subjective human assessment as well as manual analysis of medical images. Both factors limit the sensitivity in quantifying complex structural and functional phenotypes. Deep learning approaches have recently achieved success for tasks such as classification or segmentation of medical images, but lack interpretability in the feature extraction and decision processes, limiting their value in clinical diagnosis. In this work, we propose a 3D convolutional generative model for automatic classification of images from patients with cardiac diseases associated with structural remodeling. The model leverages interpretable task-specific anatomic patterns learned from 3D segmentations. It further allows to visualise and quantify the learned pathology-specific remodeling patterns in the original input space of the images. This approach yields high accuracy in the categorization of healthy and hypertrophic cardiomyopathy subjects when tested on unseen MR images from our own multi-centre dataset (100%) as well on the ACDC MICCAI 2017 dataset (90%). We believe that the proposed deep learning approach is a promising step towards the development of interpretable classifiers for the medical imaging domain, which may help clinicians to improve diagnostic accuracy and enhance patient risk-stratification.
Issue Date: 16-Sep-2018
Date of Acceptance: 25-May-2018
URI: http://hdl.handle.net/10044/1/72713
DOI: https://dx.doi.org/10.1007/978-3-030-00934-2_52
ISBN: 9783030009335
ISSN: 0302-9743
Publisher: Springer
Start Page: 464
End Page: 471
Journal / Book Title: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume: 11071 LNCS
Copyright Statement: © Springer Nature Switzerland AG 2018. The final publication is available at Springer via https://link.springer.com/chapter/10.1007%2F978-3-030-00934-2_52
Sponsor/Funder: British Heart Foundation
The Academy of Medical Sciences
Imperial College Healthcare NHS Trust- BRC Funding
British Heart Foundation
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: RE/08/002/23906
Conference Name: International Conference On Medical Image Computing & Computer Assisted Intervention
Keywords: Science & Technology
Computer Science, Theory & Methods
Computer Science
08 Information and Computing Sciences
Artificial Intelligence & Image Processing
Publication Status: Published
Start Date: 2018-09-16
Finish Date: 2018-09-20
Conference Place: Granada, Spain
Online Publication Date: 2018-09-26
Appears in Collections:Computing
Department of Brain Sciences
Faculty of Engineering