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Simulation of a radiobiology facility for the Centre for the Clinical Application of Particles

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Title: Simulation of a radiobiology facility for the Centre for the Clinical Application of Particles
Authors: Kurup, A
Pasternak, J
Taylor, R
Murgatroyd, L
Ettlinger, O
Shields, W
Nevay, L
Gruber, S
Pozimski, J
Lau, HT
Long, K
Blackmore, V
Barber, G
Najmudin, Z
Yarnold, J
Item Type: Journal Article
Abstract: The Centre for the Clinical Application of Particles’ Laser-hybrid Accelerator for Radiobiological Applications (LhARA) facility is being studied and requires simulation of novel accelerator components (such as the Gabor lens capture system), detector simulation and simulation of the ion beam interaction with cells. The first stage of LhARA will provide protons up to 15 MeV for in vitro studies. The second stage of LhARA will use a fixed-field accelerator to increase the energy of the particles to allow in vivo studies with protons and in vitro studies with heavier ions. BDSIM, a Geant4 based accelerator simulation tool, has been used to perform particle tracking simulations to verify the beam optics design done by BeamOptics and these show good agreement. Design parameters were defined based on an EPOCH simulation of the laser source and a series of mono-energetic input beams were generated from this by BDSIM. The tracking results show the large angular spread of the input beam (0.2 rad) can be transported with a transmission of almost 100% whilst keeping divergence at the end station very low (<0.1 mrad). The legacy of LhARA will be the demonstration of technologies that could drive a step-change in the provision of proton and light ion therapy (i.e. a laser source coupled to a Gabor lens capture and a fixed-field accelerator), and a system capable of delivering a comprehensive set of experimental data that can be used to enhance the clinical application of proton and light ion therapy.
Issue Date: 1-Sep-2019
Date of Acceptance: 7-Jul-2019
URI: http://hdl.handle.net/10044/1/72680
DOI: 10.1016/j.ejmp.2019.07.003
ISSN: 1120-1797
Publisher: Elsevier BV
Start Page: 21
End Page: 28
Journal / Book Title: Physica Medica
Volume: 65
Issue: 10
Copyright Statement: © 2019 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Engineering & Physical Science Research Council (E
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Imperial College Trust
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Science and Technology Facilities Council (STFC)
Funder's Grant Number: EP/K022415/1
ST/P000835/1
ST/P002021/1
PP/E000509/1
ST/H000992/1
ST/H000992/2
ST/K001604/1
PR1200SB
PHHE_P52636
4070103442
PR120056
4070194718
ST/N000242/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
Radiobiology
Laser
Ion
Beam
RELATIVE BIOLOGICAL EFFECTIVENESS
BEAM THERAPY
PROTON
DOSIMETRY
IRRADIATION
SELECTION
Beam
Ion
Laser
Radiobiology
Models, Theoretical
Particle Accelerators
Radiobiology
Radiobiology
Particle Accelerators
Models, Theoretical
physics.acc-ph
physics.acc-ph
physics.med-ph
02 Physical Sciences
06 Biological Sciences
11 Medical and Health Sciences
Nuclear Medicine & Medical Imaging
Publication Status: Published
Open Access location: http://arxiv.org/abs/arXiv:1907.10157
Online Publication Date: 2019-08-10
Appears in Collections:Physics
Plasma Physics
High Energy Physics
Faculty of Natural Sciences