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Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load

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Title: Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load
Authors: Boyle, C
Plotczyk, M
Fayos Villalta, S
Patel, S
Hettiaratchy, S
Masouros, S
Masen, M
Higgins, C
Item Type: Journal Article
Abstract: Plantar skin on the soles of the feet has a distinct morphology and composition that is thought to enhance its tolerance to mechanical loads, although the individual contributions of morphology and composition have never been quantified. Here, we combine multiscale mechanical testing and computational models of load bearing to quantify the mechanical environment of both plantar and nonplantar skin under load. We find that morphology and composition play distinct and complementary roles in plantar skin’s load tolerance. More specifically, the thick stratum corneum provides protection from stress-based injuries such as skin tears and blisters, while epidermal and dermal compositions provide protection from deformation-based injuries such as pressure ulcers. This work provides insights into the roles of skin morphology and composition more generally and will inform the design of engineered skin substitutes as well as the etiology of skin injury.
Issue Date: 2-Oct-2019
Date of Acceptance: 19-Jul-2019
URI: http://hdl.handle.net/10044/1/72315
DOI: 10.1126/sciadv.aay0244
ISSN: 2375-2548
Publisher: American Association for the Advancement of Science
Start Page: 1
End Page: 13
Journal / Book Title: Science Advances
Volume: 5
Issue: 10
Copyright Statement: © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Netherlands Organisation for Scientific Research
Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: EP/N026845/1
STW 12673
BB/L015129/1
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
PRESSURE ULCERS
AGING SKIN
COMPRESSION
ADAPTATION
FRICTION
WOUNDS
DEEP
FOOT
Collagen Type I
Epidermis
Humans
Microscopy, Atomic Force
Skin
Stress, Mechanical
Epidermis
Skin
Humans
Collagen Type I
Microscopy, Atomic Force
Stress, Mechanical
Publication Status: Published
Article Number: eaay0244
Online Publication Date: 2019-10-09
Appears in Collections:Mechanical Engineering
Bioengineering
Faculty of Engineering