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Closed-loop implantable therapeutic neuromodulation systems based on neurochemical monitoring

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Title: Closed-loop implantable therapeutic neuromodulation systems based on neurochemical monitoring
Authors: Mirza, KB
Golden, C
Nikolic, K
Toumazou, C
Item Type: Journal Article
Abstract: Closed-loop or intelligent neuromodulation allows adjustable, personalised neuromodulation which usually incorporates the recording of a biomarker, followed by implementation of an algori5 thm which decides the timing (when ?) and strength (how much ?) of stimulation. Closed-loop neuromodulation has been shown to have greater benefits compared to open-loop neuromodu lation, particularly for therapeutic applications such as pharmacoresistant epilepsy, movement disorders and potentially for psychological disorders such as depression or drug addiction. How ever, an important aspect of the technique is selection of an appropriate, preferably neural biomarker. Neurochemical sensing can provide high resolution biomarker monitoring for various neurological disorders as well as offer deeper insight into neurological mechanisms. The chemicals of interest being measured, could be ions such as potassium (K+), sodium (Na+ 12 ), calcium (Ca2+), chloride (Cl−), hydrogen (H+ 13 ) or neurotransmitters such as dopamine, serotonin and glutamate. This review focusses on the different building blocks necessary for a neurochemi cal, closed-loop neuromodulation system including biomarkers, sensors and data processing algorithms. Furthermore, it also highlights the merits and drawbacks of using this biomarker modality.
Issue Date: 20-Aug-2019
Date of Acceptance: 19-Jul-2019
URI: http://hdl.handle.net/10044/1/72210
DOI: 10.3389/fnins.2019.00808
ISSN: 1662-4548
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Neuroscience
Volume: 13
Copyright Statement: © 2019 Mirza, Golden, Nikolic and Toumazou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Commission of the European Communities
European Research Council
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: 319818
319818
EP/N002474/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
neurochemical monitoring
closed loop neuromodulation
deep brain stimulation (DBS)
vagus nerve stimulation (VNS)
FSCV
chemometrics
DEEP-BRAIN-STIMULATION
VAGUS NERVE-STIMULATION
SCAN CYCLIC VOLTAMMETRY
SUBTHALAMIC NUCLEUS
PREFRONTAL CORTEX
DOPAMINE ANTAGONISTS
PARKINSONS-DISEASE
MOVEMENT-DISORDERS
COORDINATED RESET
EXTRACELLULAR PH
FSCV
chemometrics
closed loop neuromodulation
deep brain stimulation (DBS)
neurochemical monitoring
vagus nerve stimulation (VNS)
1109 Neurosciences
1702 Cognitive Sciences
1701 Psychology
Publication Status: Published
Article Number: ARTN 808
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering



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