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Prevention of liver fibrosis and liver cancer linked to hepatitis B virus in Africa: the Prolifica study

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Title: Prevention of liver fibrosis and liver cancer linked to hepatitis B virus in Africa: the Prolifica study
Authors: Cohen, D
Shimakawa, Y
Ndow, G
Sow, A
Tamba, S
Njie, R
Lo, G
Ghosh, S
Toure-Kane, C
Ka, M
Mboup, S
Okeke, E
Toure, S
Diop, M
D'Alessandro, U
Taylor-Robinson, S
Mendy, M
Zoulim, F
Thursz, MR
Lemoine, M
Chemin, I
Item Type: Journal Article
Abstract: Despite the existence of an effective vaccine, HBV infects 257 million people worldwide and is the cause of the majority of HCC. With an annual mortality rate of 887 000 patients in 2015, this cancer is the second deadliest. Low-income countries such as ones in sub-Saharan Africa are the most at risk due to the limited access to healthcare. To overcome this and born from an international research collaboration within an EU project, the Prolifica study aimed at evaluating a screen-and-treat program to prevent HBV complications, and more particularly HCC. Based on communities, facilities and hospitals HBsAg+ detection, the study lasted from 2011 to 2016. From the “cost effectiveness” feasibility of such a program to the development of simple scores for antiviral treatment, Prolifica uncovered data of crucial importance in a region with low HBV infection awareness, transmissions modes and prevention means which could have impacts on public health policies.
Issue Date: 1-May-2019
Date of Acceptance: 1-May-2019
URI: http://hdl.handle.net/10044/1/72158
DOI: https://doi.org/10.1051/medsci/2019076
ISSN: 0767-0974
Publisher: EDP Sciences
Start Page: 431
End Page: 439
Journal / Book Title: médecine/sciences
Volume: 35
Issue: 5
Copyright Statement: © 2019 médecine/sciences – Inserm. Article publié sous les conditions définies par la licence Creative Commons Attribution License CC-BY (http://creativecommons.org/licenses/by/4.0), qui autorise sans restrictions l'utilisation, la diffusion, et la reproduction sur quelque support que ce soit, sous réserve de citation correcte de la publication originale.
Sponsor/Funder: Wellcome Trust
Wellcome Trust
British Liver Trust
Medical Research Council
Funder's Grant Number: 097816/Z/11/ZR
097816/Z/11/A
N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
PRACTICE GUIDELINES MANAGEMENT
HEPATOCELLULAR-CARCINOMA
VIRAL-HEPATITIS
GAMBIA
INFECTION
VALIDATION
DIAGNOSIS
RISK
DNA
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
PRACTICE GUIDELINES MANAGEMENT
HEPATOCELLULAR-CARCINOMA
VIRAL-HEPATITIS
GAMBIA
INFECTION
VALIDATION
DIAGNOSIS
RISK
DNA
General & Internal Medicine
Publication Status: Published
Online Publication Date: 2019-05-22
Appears in Collections:Department of Surgery and Cancer