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GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits

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Title: GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits
Authors: Pazoki, R
Evangelou, E
Mosen-Ansorena, D
Pinto, R
Karaman, I
Blakeley, P
Gill, D
Zuber, V
Elliott, P
Tzoulaki, I
Dehghan, A
Item Type: Journal Article
Abstract: Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 51 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits.
Issue Date: 13-Aug-2019
Date of Acceptance: 27-Jun-2019
URI: http://hdl.handle.net/10044/1/71729
DOI: 10.1038/s41467-019-11451-y
ISSN: 2041-1723
Publisher: Nature Research
Journal / Book Title: Nature Communications
Volume: 10
Issue: 1
Copyright Statement: © The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Sponsor/Funder: Health Data Research Uk
Medical Research Council (MRC)
Funder's Grant Number: Health Data Research UK
MR/R026505/1
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
GENOME-WIDE ASSOCIATION
LD SCORE REGRESSION
BLOOD-PRESSURE
MENDELIAN RANDOMIZATION
SERUM SODIUM
GENOTYPE
INSULIN
BIAS
POLYMORPHISMS
CONSUMPTION
Publication Status: Published
Article Number: 3653
Appears in Collections:School of Public Health