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Psychological distress is more prevalent in fertile age and premenopausal women with PCOS symptoms: 15-year follow-up

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Title: Psychological distress is more prevalent in fertile age and premenopausal women with PCOS symptoms: 15-year follow-up
Authors: Karjula, S
Morin-Papunen, L
Auvinen, J
Ruokonen, A
Puukka, K
Franks, S
Jarvelin, M-R
Tapanainen, JS
Jokelainen, J
Miettunen, J
Piltonen, TT
Item Type: Journal Article
Abstract: Context: Polycystic ovary syndrome (PCOS) is associated with increased psychological distress, obesity and hyperandrogenism being suggested as key promoters. Objectives: To investigate the prevalence of anxiety/depression and their coexistence in women with PCOS/PCOS-related symptoms at ages 31 and 46. The roles of obesity, hyperandrogenism, and awareness of PCOS on psychological distress were also assessed. Design: Population-based follow-up. Setting: Northern Finland Birth Cohort 1966 with 15-year follow-up. Participants: At age 31, a questionnaire-based screening for oligoamenorrhea (OA) and hirsutism (H): 2188 asymptomatic (controls), 331 OA, 323 H, and 125 OA plus H (PCOS). Follow-up at age 46: 1576 controls, 239 OA, 231 H, and 85 PCOS. Interventions: Questionnaire-based screening for anxiety and depression symptoms (Hopkins Symptom Checklist-25) and previously diagnosed/treated depression at ages 31 and 46. Body mass index (BMI), serum testosterone/free androgen index, and awareness of polycystic ovaries/PCOS on psychological distress were also assessed. Main Outcomes: Population-based prevalence of anxiety and/or depression in women with PCOS/PCOS-related symptoms at ages 31 and 46. Results: Anxiety and/or depression symptoms, their coexistence, and rate of depression were increased at ages 31 and 46 in women with PCOS or isolated H compared with controls. High BMI or hyperandrogenism did not associate with increased anxiety or depression symptoms. The awareness of PCOS was associated with increased anxiety. Conclusions: Women with PCOS or isolated H present more often with anxiety and/or depression symptoms and their coexistence compared with controls. High BMI or hyperandrogenism did not provoke psychological distress in PCOS. The awareness of PCOS increased anxiety but did not associate with severe anxiety or depression.
Issue Date: 1-Jun-2017
Date of Acceptance: 22-Feb-2017
URI: http://hdl.handle.net/10044/1/71646
DOI: https://dx.doi.org/10.1210/jc.2016-3863
ISSN: 1945-7197
Publisher: Endocrine Society
Start Page: 1861
End Page: 1869
Journal / Book Title: Journal of Clinical Endocrinology & Metabolism
Volume: 102
Issue: 6
Copyright Statement: © 2017 The Author(s). This article has been published under the terms of the Creative Commons AttributionLicense (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited. Copyright for this article is retained by the author(s)
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
MRC
Medical Research Council (MRC)
Funder's Grant Number: RDD03 79560
G0802782
G0802782
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
POLYCYSTIC-OVARY-SYNDROME
QUALITY-OF-LIFE
OLIGOMENORRHEA AND/OR HIRSUTISM
SELF-REPORTED SYMPTOMS
DEPRESSIVE SYMPTOMS
INCREASED RISK
FACIAL HAIR
ANXIETY
HEALTH
CHECKLIST-25
Adult
Anxiety
Depression
Female
Finland
Hirsutism
Humans
Hyperandrogenism
Middle Aged
Obesity
Oligomenorrhea
Polycystic Ovary Syndrome
Premenopause
Prevalence
Stress, Psychological
Surveys and Questionnaires
Humans
Polycystic Ovary Syndrome
Hirsutism
Obesity
Hyperandrogenism
Oligomenorrhea
Prevalence
Depression
Stress, Psychological
Anxiety
Premenopause
Adult
Middle Aged
Finland
Female
Surveys and Questionnaires
Endocrinology & Metabolism
1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Online Publication Date: 2017-02-27
Appears in Collections:Department of Surgery and Cancer