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Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort

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Title: Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort
Authors: Aglago, EK
Huybrechts, I
Murphy, N
Casagrande, C
Nicolas, G
Pischon, T
Fedirko, V
Severi, G
Boutron-Ruault, M-C
Fournier, A
Katzke, V
Kühn, T
Olsen, A
Tjønneland, A
Dahm, CC
Overvad, K
Lasheras, C
Agudo, A
Sánchez, M-J
Amiano, P
Huerta, JM
Ardanaz, E
Perez-Cornago, A
Trichopoulou, A
Karakatsani, A
Martimianaki, G
Palli, D
Pala, V
Tumino, R
Naccarati, A
Panico, S
Bueno-de-Mesquita, B
May, A
Derksen, JWG
Hellstrand, S
Ohlsson, B
Wennberg, M
Van Guelpen, B
Skeie, G
Brustad, M
Weiderpass, E
Cross, AJ
Ward, H
Riboli, E
Norat, T
Chajes, V
Gunter, MJ
Item Type: Journal Article
Abstract: BACKGROUND & AIMS: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. RESULTS: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80-0.96; Ptrend=.005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82-0.98; Ptrend=.009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83-1.00; Ptrend=.016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78-0.95; Ptrend=.010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18-1.45; Ptrend<.001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (Pheterogeneity=.026). CONCLUSIONS: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon.
Issue Date: Mar-2020
Date of Acceptance: 16-Jun-2019
URI: http://hdl.handle.net/10044/1/71616
DOI: 10.1016/j.cgh.2019.06.031
ISSN: 1542-3565
Publisher: Elsevier
Start Page: 654
End Page: 666.e6
Journal / Book Title: Clinical Gastroenterology and Hepatology
Volume: 18
Issue: 3
Copyright Statement: © 2019 by the AGA Institute. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Epidemiologic
Omega 3
Seafood
Tumorigenesis
epidemiologic
omega 3
seafood
tumorigenesis
Gastroenterology & Hepatology
1103 Clinical Sciences
Publication Status: Published
Conference Place: United States
Online Publication Date: 2019-06-25
Appears in Collections:School of Public Health