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Nutritional ketosis alters fuel preference and thereby endurance Performance in athletes

Title: Nutritional ketosis alters fuel preference and thereby endurance Performance in athletes
Authors: Cox, PJ
Kirk, T
Ashmore, T
Willerton, K
Evans, R
Smith, A
Murray, AJ
Stubbs, B
West, J
McLure, SW
King, MT
Dodd, MS
Holloway, C
Neubauer, S
Drawer, S
Veech, RL
Griffin, JL
Clarke, K
Item Type: Journal Article
Abstract: Ketosis, the metabolic response to energy crisis, is a mechanism to sustain life by altering oxidative fuel selection. Often overlooked for its metabolic potential, ketosis is poorly understood outside of starvation or diabetic crisis. Thus, we studied the biochemical advantages of ketosis in humans using a ketone ester-based form of nutrition without the unwanted milieu of endogenous ketone body production by caloric or carbohydrate restriction. In five separate studies of 39 high-performance athletes, we show how this unique metabolic state improves physical endurance by altering fuel competition for oxidative respiration. Ketosis decreased muscle glycolysis and plasma lactate concentrations, while providing an alternative substrate for oxidative phosphorylation. Ketosis increased intramuscular triacylglycerol oxidation during exercise, even in the presence of normal muscle glycogen, co-ingested carbohydrate and elevated insulin. These findings may hold clues to greater human potential and a better understanding of fuel metabolism in health and disease.
Issue Date: 9-Aug-2016
Date of Acceptance: 17-Jul-2016
URI: http://hdl.handle.net/10044/1/71473
DOI: https://dx.doi.org/10.1016/j.cmet.2016.07.010
ISSN: 1550-4131
Publisher: Elsevier (Cell Press)
Start Page: 256
End Page: 268
Journal / Book Title: Cell Metabolism
Volume: 24
Issue: 2
Copyright Statement: © 2016 Elsevier Inc. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Adiposity
Athletes
Carbohydrates
Carnitine
Diet
Energy Metabolism
Exercise
Female
Glycogen
Humans
Ketone Bodies
Ketosis
Male
Muscle, Skeletal
Physical Endurance
Rest
Muscle, Skeletal
Humans
Ketosis
Ketone Bodies
Glycogen
Carbohydrates
Carnitine
Exercise
Diet
Energy Metabolism
Physical Endurance
Rest
Female
Male
Adiposity
Athletes
Adiposity
Athletes
Carbohydrates
Carnitine
Diet
Energy Metabolism
Exercise
Female
Glycogen
Humans
Ketone Bodies
Ketosis
Male
Muscle, Skeletal
Physical Endurance
Rest
0601 Biochemistry and Cell Biology
1101 Medical Biochemistry and Metabolomics
Endocrinology & Metabolism
Publication Status: Published
Conference Place: United States
Online Publication Date: 2016-07-27
Appears in Collections:Division of Surgery



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