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Body size and obesity during adulthood, and risk of lympho-hematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies.

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Title: Body size and obesity during adulthood, and risk of lympho-hematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies.
Authors: Abar, L
Sobiecki, JG
Cariolou, M
Nanu, N
Vieira, AR
Stevens, C
Aune, D
Greenwood, DC
Chan, DSM
Norat, T
Item Type: Journal Article
Abstract: Background: To summarise the evidence on the associations between body mass index (BMI) and BMI in early adulthood, height, waist circumference (WC) and waist to hip ratio (WHR), and risk of lympho-hematopoietic cancers. Method: We conducted a meta-analysis of prospective studies and identified relevant studies published up to December 2017 by searching PubMed. A random effects model was used to calculate dose-response summary relative risks (RRs). Results: Our findings showed BMI, and BMI in early adulthood (aged 18-21 years) is associated with the risk of Hodgkin's and Non-Hodgkin's lymphoma (HL and NHL), Diffuse Large Beta Cell Lymphoma (DLBCL), Leukaemia including Acute and Chronic Myeloid Lymphoma (AML and CML), and Chronic Lymphocytic Leukaemia (CLL) and Multiple Myeloma. The summary RR per 5 kg/m2 increase in BMI were 1.12 (95% CI: 1.05-1.20) for HL, 1.05 (95% CI:1.03-1.08) for NHL, 1.11 (95% CI:1.05-1.16) for DLBCL, 1.06 (95% CI:1.03-1.09) for ML, 1.09 (95% CI:1.03-1.15) for leukaemia, 1.13 (95% CI:1.04-1.24) for AML, 1.13 (95% CI:1.05-1.22) for CML and 1.04 (95% CI:1.00-1.09) for CLL, and were1.12 (95% CI:1.05-1.19) for NHL, 1.22 (95% CI:1.09-1.37) for DLBCL, and 1.19 (95% CI:1.03-1.38) for FL for BMI in early adulthood analysis.Results on mortality showed a 15%, 16% and 17% increased risk of NHL, multiple myeloma and leukaemia, respectively. Greater height increased the risk of NHL by 7%, DLBCL by 10%, FL by 9%, multiple myeloma by 5%, and Leukaemia by 7%. WHR was associated with increased risk of DLBCL by 12%. No association was found between higher WC and risk of multiple myeloma. Conclusion: Our results revealed that general adiposity in adulthood and early adulthood, and greater height may increase the risk of almost all types of lympho-hematopoietic cancers and this adds to a growing body of evidence linking body fatness to several types of cancers.
Issue Date: 1-Apr-2019
Date of Acceptance: 1-Feb-2019
URI: http://hdl.handle.net/10044/1/71436
DOI: https://doi.org/10.1093/annonc/mdz045
ISSN: 0923-7534
Publisher: Oxford University Press (OUP)
Journal / Book Title: Annals of Oncology
Volume: 30
Issue: 4
Copyright Statement: © 2019 European Society for Medical Oncology. This is a pre-copy-editing, author-produced version of an article accepted for publication in Annals of Oncology following peer review. The definitive publisher-authenticated version L Abar, J G Sobiecki, M Cariolou, N Nanu, A R Vieira, C Stevens, D Aune, D C Greenwood, D S M Chan, T Norat, Body size and obesity during adulthood, and risk of lympho-haematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies, Annals of Oncology, Volume 30, Issue 4, April 2019, Pages 528–541, is available online at: https://doi.org/10.1093/annonc/mdz045
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
met analysis BMI lymphoma
met analysis BMI leukaemia
met analysis BMI myeloma
met analysis height lympho-haematopoietic cancer
met analysis abdominal obesity lympho-haematopoietic cancer
met analysis general obesity lymphoma
NON-HODGKINS-LYMPHOMA
NIH-AARP DIET
DIFFERENT ANATOMIC SITES
MASS INDEX
PHYSICAL-ACTIVITY
MULTIPLE-MYELOMA
ANTHROPOMETRIC CHARACTERISTICS
HEMATOLOGICAL MALIGNANCY
NATIONWIDE COHORT
CIGARETTE-SMOKING
met analysis BMI leukaemia
met analysis BMI lymphoma
met analysis BMI myeloma
met analysis abdominal obesity lympho-haematopoietic cancer
met analysis general obesity lymphoma
met analysis height lympho-haematopoietic cancer
Oncology & Carcinogenesis
1112 Oncology and Carcinogenesis
Publication Status: Published online
Conference Place: England
Online Publication Date: 2019-02-07
Appears in Collections:School of Public Health