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Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor

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Title: Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor
Authors: Nightingale, AM
Leong, CL
Burnish, RA
Hassan, S-U
Zhang, Y
Clough, GF
Boutelle, MG
Voegeli, D
Niu, X
Item Type: Journal Article
Abstract: Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels.
Issue Date: 21-Jun-2019
Date of Acceptance: 7-May-2019
URI: http://hdl.handle.net/10044/1/71331
DOI: 10.1038/s41467-019-10401-y
ISSN: 2041-1723
Publisher: Nature Research
Start Page: 1
End Page: 12
Journal / Book Title: Nature Communications
Volume: 10
Issue: 1
Copyright Statement: © 2019 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MICRODIALYSIS PROBE
SEGMENTED FLOW
GLUCOSE
BIOSENSORS
INJECTION
OXIDASE
DEVICES
SYSTEM
BLOOD
CHIP
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MICRODIALYSIS PROBE
SEGMENTED FLOW
GLUCOSE
BIOSENSORS
INJECTION
OXIDASE
DEVICES
SYSTEM
BLOOD
CHIP
Biomarkers
Blood Glucose
Equipment Design
Glucose
Healthy Volunteers
Humans
Lab-On-A-Chip Devices
Lactic Acid
Microdialysis
Microfluidic Analytical Techniques
Point-of-Care Systems
Skin
Wearable Electronic Devices
Skin
Humans
Lactic Acid
Glucose
Blood Glucose
Microdialysis
Microfluidic Analytical Techniques
Equipment Design
Point-of-Care Systems
Lab-On-A-Chip Devices
Healthy Volunteers
Biomarkers
Wearable Electronic Devices
Publication Status: Published online
Article Number: 2741
Online Publication Date: 2019-06-21
Appears in Collections:Bioengineering
Faculty of Engineering