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The cancer genome atlas comprehensive molecular characterization of renal cell carcinoma

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Title: The cancer genome atlas comprehensive molecular characterization of renal cell carcinoma
Authors: Ricketts, CJ
De Cubas, AA
Fan, H
Smith, CC
Lang, M
Reznik, E
Bowlby, R
Gibb, EA
Akbani, R
Beroukhim, R
Bottaro, DP
Choueiri, TK
Gibbs, RA
Godwin, AK
Haake, S
Hakimi, AA
Henske, EP
Hsieh, JJ
Ho, TH
Kanchi, RS
Krishnan, B
Kwaitkowski, DJ
Lui, W
Merino, MJ
Mills, GB
Myers, J
Nickerson, ML
Reuter, VE
Schmidt, LS
Shelley, CS
Shen, H
Shuch, B
Signoretti, S
Srinivasan, R
Tamboli, P
Thomas, G
Vincent, BG
Vocke, CD
Wheeler, DA
Yang, L
Kim, WT
Robertson, AG
Spellman, PT
Rathmell, WK
Linehan, WM
Item Type: Journal Article
Abstract: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.
Issue Date: 3-Apr-2018
Date of Acceptance: 19-Mar-2018
URI: http://hdl.handle.net/10044/1/71226
DOI: https://doi.org/10.1016/j.celrep.2018.03.075
ISSN: 2211-1247
Publisher: Elsevier
Start Page: 313
End Page: 326.e5
Journal / Book Title: Cell Reports
Volume: 23
Issue: 1
Copyright Statement: © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: SAIC-F-Frederick, Inc
Leidos Biomedical Research, Inc.
Funder's Grant Number: TCGA Pilot Program
15Y011ST
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
SOMATIC POINT MUTATIONS
SEQUENCING DATA
RNA-SEQ
CLASS DISCOVERY
MESSENGER-RNA
KIDNEY CANCER
GENETIC-BASIS
EXPRESSION
BREAST
DNA
CDKN2A
DNA hypermethylation
PanCanAtlas
TCGA
chromatin remodeling
chromophobe renal cell carcinoma
clear cell renal cell carcinoma
immune signature
papillary renal cell carcinoma
Cancer Genome Atlas Research Network
Science & Technology
Life Sciences & Biomedicine
Cell Biology
SOMATIC POINT MUTATIONS
SEQUENCING DATA
RNA-SEQ
CLASS DISCOVERY
MESSENGER-RNA
KIDNEY CANCER
GENETIC-BASIS
EXPRESSION
BREAST
DNA
Publication Status: Published
Online Publication Date: 2018-04-05
Appears in Collections:Department of Surgery and Cancer