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Perspective on oncogenic processes at the end of the beginning of cancer genomics

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Title: Perspective on oncogenic processes at the end of the beginning of cancer genomics
Authors: Ding, L
Bailey, MH
Porta-Pardo, E
Thorsson, V
Colaprico, A
Bertrand, D
Gibbs, DL
Weerasinghe, A
Huang, K-L
Tokheim, C
Cortes-Ciriano, I
Jayasinghe, R
Chen, F
Yu, L
Sun, S
Olsen, C
Kim, J
Taylor, AM
Cherniack, AD
Akbani, R
Suphavilai, C
Nagarajan, N
Stuart, JM
Mills, GB
Wyczalkowski, MA
Vincent, BG
Hutter, CM
Zenklusen, JC
Hoadley, KA
Wendl, MC
Shmulevich, L
Lazar, AJ
Wheeler, DA
Getz, G
Item Type: Journal Article
Abstract: The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.
Issue Date: 5-Apr-2018
Date of Acceptance: 13-Mar-2018
URI: http://hdl.handle.net/10044/1/71217
DOI: https://doi.org/10.1016/j.cell.2018.03.033
ISSN: 0092-8674
Publisher: Elsevier
Start Page: 305
End Page: 320.e10
Journal / Book Title: Cell
Volume: 173
Issue: 2
Copyright Statement: © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Sponsor/Funder: SAIC-F-Frederick, Inc
Leidos Biomedical Research, Inc.
Funder's Grant Number: TCGA Pilot Program
15Y011ST
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
SOMATIC POINT MUTATIONS
DISCOVERY
CLASSIFICATION
EXPRESSION
BREAST
TUMORS
LANDSCAPE
DRIVER
IDENTIFICATION
INFORMATION
TCGA
cancer
cancer genomics
omics
oncogenic process
Carcinogenesis
DNA Repair
Databases, Genetic
Genes, Neoplasm
Genomics
Humans
Metabolic Networks and Pathways
Microsatellite Instability
Mutation
Neoplasms
Transcriptome
Tumor Microenvironment
Cancer Genome Atlas Research Network
Humans
Neoplasms
Genomics
DNA Repair
Mutation
Databases, Genetic
Genes, Neoplasm
Microsatellite Instability
Metabolic Networks and Pathways
Tumor Microenvironment
Transcriptome
Carcinogenesis
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
SOMATIC POINT MUTATIONS
DISCOVERY
CLASSIFICATION
EXPRESSION
BREAST
TUMORS
LANDSCAPE
DRIVER
IDENTIFICATION
INFORMATION
06 Biological Sciences
11 Medical and Health Sciences
Developmental Biology
Publication Status: Published
Open Access location: https://www.cell.com/cell/fulltext/S0092-8674(18)30313-1?_returnURL=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418303131%3Fshowall%3Dtrue
Online Publication Date: 2018-04-05
Appears in Collections:Department of Surgery and Cancer