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The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations

Title: The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations
Authors: Leach, MO
Brindle, KM
Evelhoch, JL
Griffiths, JR
Horsman, MR
Jackson, A
Jayson, GC
Judson, IR
Knopp, MV
Maxwell, RJ
McIntyre, D
Padhani, AR
Price, P
Rathbone, R
Rustin, GJ
Tofts, PS
Tozer, GM
Vennart, W
Waterton, JC
Williams, SR
Workmanw, P
Item Type: Conference Paper
Abstract: Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that considered the methodology and design of magnetic resonance studies, recommending how this new tool might best be used.
Issue Date: 3-May-2005
Date of Acceptance: 7-Mar-2005
URI: http://hdl.handle.net/10044/1/71109
DOI: https://doi.org/10.1038/sj.bjc.6602550
ISSN: 0007-0920
Publisher: Springer Nature
Start Page: 1599
End Page: 1610
Journal / Book Title: British Journal of Cancer
Volume: 92
Issue: 9
Copyright Statement: © 2005 Cancer Research UK. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
Conference Name: 94th Annual Meeting of the American-Association-for-Cancer-Research
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
biomarker
magnetic resonance
therapeutic trials
antiangiogenic
antivascular
cancer therapy
CONTRAST-ENHANCED MRI
ENDOTHELIAL GROWTH-FACTOR
CEREBRAL BLOOD-VOLUME
BRAIN-TUMORS
GADOPENTETATE DIMEGLUMINE
QUANTITATIVE-ANALYSIS
BREAST-TUMORS
END-POINTS
CANCER
ANGIOGENESIS
Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee, Drug Development Office, Cancer Research UK
Neoplasms
Angiogenesis Inhibitors
Antineoplastic Agents
Magnetic Resonance Imaging
Reproducibility of Results
Clinical Trials as Topic
Evaluation Studies as Topic
Terminology as Topic
Science & Technology
Life Sciences & Biomedicine
Oncology
biomarker
magnetic resonance
therapeutic trials
antiangiogenic
antivascular
cancer therapy
CONTRAST-ENHANCED MRI
ENDOTHELIAL GROWTH-FACTOR
CEREBRAL BLOOD-VOLUME
BRAIN-TUMORS
GADOPENTETATE DIMEGLUMINE
QUANTITATIVE-ANALYSIS
BREAST-TUMORS
END-POINTS
CANCER
ANGIOGENESIS
Oncology & Carcinogenesis
1112 Oncology and Carcinogenesis
Publication Status: Published
Start Date: 2003-07-11
Finish Date: 2003-07-14
Conference Place: Washington, DC, United States
Online Publication Date: 2005-05-03
Appears in Collections:Department of Surgery and Cancer