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The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications

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Title: The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications
Authors: Allegretti, JR
Mullish, BH
Kelly, C
Fischer, M
Item Type: Journal Article
Abstract: Recent developments in high-throughput microbial genomic sequencing and other systems biology techniques have allowed novel insight into the potential contribution of the gut microbiota to health and disease. Consequently, an increasing number of disease states have been found to be characterizedby distinctive changes in the composition and functionality of the gut microbiota; however, whether such changes are cause, consequence or incidental to the disease in question remains largely uncertain. Restoration of the gut microbiota to a pre-morbid state isa novel therapeutic approachof key interest, and faecal microbiota transplantation (FMT) –the transfer of pre-screened stool from healthy donors into the gastrointestinal tract of affected patients –is gaining increasing importance in both the clinical and research settings. At present, FMT is only recommended in the treatment of recurrent Clostridioides difficile infection, although there are a large number of ongoing trials worldwide exploring other potential therapeutic indications.
Issue Date: 3-Aug-2019
Date of Acceptance: 17-May-2019
URI: http://hdl.handle.net/10044/1/70605
DOI: 10.1016/S0140-6736(19)31266-8
ISSN: 0140-6736
Publisher: Elsevier
Start Page: 420
End Page: 431
Journal / Book Title: The Lancet
Volume: 394
Issue: 10196
Copyright Statement: © 2019 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Medical Research Council
Medical Research Council (MRC)
Funder's Grant Number: MR/R00875/1
MR/R000875/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
CLOSTRIDIUM-DIFFICILE INFECTION
INFLAMMATORY-BOWEL-DISEASE
ACTIVE ULCERATIVE-COLITIS
INTESTINAL MICROBIOTA
INSULIN SENSITIVITY
CONTROLLED-TRIAL
GUT MICROBIOTA
UNITED-STATES
HOST-DISEASE
DOUBLE-BLIND
Clostridium Infections
Fecal Microbiota Transplantation
Gastrointestinal Microbiome
Humans
Practice Guidelines as Topic
Randomized Controlled Trials as Topic
Treatment Outcome
Humans
Clostridium Infections
Treatment Outcome
Randomized Controlled Trials as Topic
Practice Guidelines as Topic
Gastrointestinal Microbiome
Fecal Microbiota Transplantation
General & Internal Medicine
11 Medical and Health Sciences
Publication Status: Accepted
Online Publication Date: 2019-08-01
Appears in Collections:Department of Metabolism, Digestion and Reproduction