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Pervasive wearable device for free tissue transfer monitoring based on advanced data analysis: clinical study report

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Title: Pervasive wearable device for free tissue transfer monitoring based on advanced data analysis: clinical study report
Authors: Berthelot, M
Henry, FP
Hunter, J
Leff, D
Wood, S
Jallali, N
Dex, E
Ladislava, L
Lo, B
Yang, GZ
Item Type: Journal Article
Abstract: Free tissue transfer (FTT) surgery for breast reconstruction following mastectomy has become a routineoperation with high success rates. Although failure is low, it can have a devastating impact on patient recovery,prognosis and psychological well-being. Continuous and objective monitoring of tissue oxygen saturation (StO2) hasshown to reduce failure rates through rapid detection time of postoperative vascular complications. We have developeda pervasive wearable wireless device that employs near infrared spectroscopy (NIRS) to continuously monitor FTTviaStO2measurement. Previously tested on different models, this paper introduces the results of a clinical study. Thegoal of the study is to demonstrate the developed device can reliably detectStO2variations in a clinical setting: 14patients were recruited. Advanced data analysis were performed on theStO2variations, the relativeStO2gradientchange, and, the classification of theStO2within different clusters of blood occlusion level (from 0% to 100% at 25%step) based on previous studies made on a vascular phantom and animals. The outcomes of the clinical study concurwith previous experimental results and the expected biological responses. This suggests the device is able to correctlydetect perfusion changes and provide real-time assessment on the viability of the FTT in a clinical setting.
Issue Date: 19-Jun-2019
Date of Acceptance: 16-May-2019
URI: http://hdl.handle.net/10044/1/70600
DOI: 10.1117/1.JBO.24.6.067001
ISSN: 1083-3668
Publisher: Society of Photo-optical Instrumentation Engineers
Start Page: 067001-1
End Page: 067001-8
Journal / Book Title: Journal of Biomedical Optics
Volume: 24
Issue: 6
Copyright Statement: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Engineering & Physical Science Research Council (EPSRC)
Engineering and Physical Sciences Research Council
Engineering & Physical Science Research Council (E
Funder's Grant Number: RDB04 79560
540213 SeNTH plus
Keywords: breast reconstruction surgery
free tissue transfer
internet of things
near-infrared spectroscopy
wearable device
0205 Optical Physics
1113 Opthalmology and Optometry
0903 Biomedical Engineering
Publication Status: Published
Online Publication Date: 2019-06-19
Appears in Collections:Department of Surgery and Cancer
Faculty of Engineering