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Charles Bonnet syndrome and periodic alternating nystagmus Moving visual hallucinations

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Title: Charles Bonnet syndrome and periodic alternating nystagmus Moving visual hallucinations
Authors: Minakaran, N
Soorma, T
Bronstein, AM
Plant, GT
Item Type: Journal Article
Abstract: Objective To describe and discuss potential mechanisms for modulation of visual hallucinations by nystagmus. Methods We present 2 patients with coexistent Charles Bonnet syndrome and periodic alternating nystagmus in the context of acquired visual loss. Results The combination has given rise to a rare phenomenon: visual hallucinations that move in a manner governed by the nystagmus, specifically by the direction and velocity of the slow phase. The perceived modulation of movement is selective for a surface in one case and a landscape in the other but not present for hallucinated individual objects and people separate from the hallucinated background visual scene. Conclusions The collision of Charles Bonnet syndrome and periodic alternating nystagmus in these 2 patients has demonstrated that some visual hallucinations can be modulated by, or collaterally with, ocular movements. We propose 2 potential mechanisms based on ocular proprioceptive input from extraocular muscles projecting to either extrastriate processing of visual scene, or to higher-order visual cortical areas involved in analysis of motion signals across the whole visual field.
Issue Date: 5-Mar-2019
Date of Acceptance: 29-Oct-2018
URI: http://hdl.handle.net/10044/1/70010
DOI: https://dx.doi.org/10.1212/WNL.0000000000007033
ISSN: 1526-632X
Publisher: American Academy of Neurology
Start Page: E1072
End Page: E1075
Journal / Book Title: Neurology
Volume: 92
Issue: 10
Copyright Statement: © 2019 American Academy of Neurology
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
Neurology & Neurosurgery
1103 Clinical Sciences
1109 Neurosciences
1702 Cognitive Sciences
Publication Status: Published
Online Publication Date: 2019-01-30
Appears in Collections:Department of Medicine (up to 2019)