A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes

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Title: A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes
Authors: Herrero, P
Bondia, J
Oliver, N
Georgiou, P
Item Type: Journal Article
Abstract: Type 1 diabetes is an autoimmune condition characterised by a pancreatic insulin secretion deficit, resulting in high blood glucose concentrations, which can lead to micro- and macrovascular complications. Type 1 diabetes also leads to impaired glucagon production by the pancreatic α-cells, which acts as a counter-regulatory hormone to insulin. A closed-loop system for automatic insulin and glucagon delivery, also referred to as an artificial pancreas, has the potential to reduce the self-management burden of type 1 diabetes and reduce the risk of hypo- and hyperglycemia. To date, bihormonal closed-loop systems for glucagon and insulin delivery have been based on two independent controllers. However, in physiology, the secretion of insulin and glucagon in the body is closely interconnected by paracrine and endocrine associations. In this work, we present a novel biologically-inspired glucose control strategy that accounts for such coordination. An in silico study using an FDA-accepted type 1 simulator was performed to evaluate the proposed coordinated control strategy compared to its non-coordinated counterpart, as well as an insulin-only version of the controller. The proposed coordinated strategy achieves a reduction of hyperglycemia without increasing hypoglycemia, when compared to its non-coordinated counterpart.
Issue Date: 20-Sep-2017
Date of Acceptance: 7-Sep-2017
ISSN: 1025-5842
Publisher: Taylor & Francis
Start Page: 1474
End Page: 1482
Journal / Book Title: Computer Methods in Biomechanics and Biomedical Engineering
Volume: 20
Issue: 13
Copyright Statement: © 2017 informa uK limited, trading as taylor & Francis group
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: 089758/Z/09/Z
WT 100921/Z/13/Z
Keywords: Science & Technology
Computer Science, Interdisciplinary Applications
Engineering, Biomedical
Computer Science
Artificial pancreas
closed-loop control
bihormonal control
glucose control
insulin delivery
Blood Glucose
Computer Simulation
Diabetes Mellitus, Type 1
Drug Delivery Systems
Pancreas, Artificial
0903 Biomedical Engineering
1105 Dentistry
Biomedical Engineering
Publication Status: Published
Appears in Collections:Electrical and Electronic Engineering
Department of Medicine

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