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Transmission-blocking effects of primaquine and methylene blue suggest P. falciparum gametocyte sterilisation rather than effects on sex ratio
| File | Description | Size | Format | |
|---|---|---|---|---|
 Transmission-blocking-Effects-of-Primaquine-and-Methylene.pdf | Published version | 850.78 kB | Adobe PDF | View/Open |
| Title: | Transmission-blocking effects of primaquine and methylene blue suggest P. falciparum gametocyte sterilisation rather than effects on sex ratio |
| Authors: | Bradley, J Soumaré, HM Mahamar, A Diawara, H Roh, M Delves, M Drakeley, C Churcher, TS Dicko, A Gosling, R Bousema, T |
| Item Type: | Journal Article |
| Abstract: | Gametocyte density and sex-ratio can predict the proportion of mosquitoes that become infected after feeding on blood of patients receiving non-gametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex-ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects. |
| Issue Date: | 15-Oct-2019 |
| Date of Acceptance: | 1-Feb-2019 |
| URI: | http://hdl.handle.net/10044/1/69053 |
| DOI: | https://doi.org/10.1093/cid/ciz134 |
| ISSN: | 1058-4838 |
| Publisher: | Oxford University Press (OUP) |
| Start Page: | 1436 |
| End Page: | 1439 |
| Journal / Book Title: | Clinical Infectious Diseases |
| Volume: | 69 |
| Issue: | 8 |
| Copyright Statement: | © 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciz134. |
| Sponsor/Funder: | PATH-Program for Appropriate Technology in Health Medical Research Council (MRC) |
| Funder's Grant Number: | GAT.0888-30-01618462-COL MR/R015600/1 |
| Keywords: | anopheles infectiousness malaria transmission treatment Microbiology 06 Biological Sciences 11 Medical and Health Sciences |
| Publication Status: | Published |
| Conference Place: | United States |
| Online Publication Date: | 2019-02-12 |
| Appears in Collections: | School of Public Health |