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Alcohol hangover: underlying biochemical, inflammatory and neurochemical mechanisms
File | Description | Size | Format | |
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Alcohol hangover combined.pdf | Accepted version | 247.6 kB | Adobe PDF | View/Open |
Title: | Alcohol hangover: underlying biochemical, inflammatory and neurochemical mechanisms |
Authors: | Palmer, E Tyacke, R Sastre, M Lingford-Hughes, A Nutt, D Ward, RJ |
Item Type: | Journal Article |
Abstract: | AIM: To review current alcohol hangover research in animals and humans and evaluate key evidence for contributing biological factors. METHOD: Narrative review with alcohol hangover defined as the state the day after a single episode of heavy drinking, when the alcohol concentration in the blood approaches zero. RESULTS: Many of the human studies of hangover are not well controlled, with subjects consuming different concentrations of alcohol over variable time periods and evaluation not blinded. Also, studies have measured different symptoms and use varying methods of measurement. Animal studies show variations with respect to the route of administration (intragastric or intraperitoneal), the behavioural tests utilised and discrepancy in the timepoint used for hangover onset. Human studies have the advantage over animal models of being able to assess subjective hangover severity and its correlation with specific behaviours and/or biochemical markers. However, animal models provide valuable insight into the neural mechanisms of hangover. Despite such limitations, several hangover models have identified pathological changes which correlate with the hangover state. We review studies examining the contribution of alcohol's metabolites, neurotransmitter changes with particular reference to glutamate, neuroinflammation and ingested congeners to hangover severity. CONCLUSION: Alcohol metabolites, neurotransmitter alterations, inflammatory factors and mitochondrial dysfunction are the most likely factors in hangover pathology. Future research should aim to investigate the relationship between these factors and their causal role. |
Issue Date: | May-2019 |
Date of Acceptance: | 6-Feb-2019 |
URI: | http://hdl.handle.net/10044/1/69032 |
DOI: | 10.1093/alcalc/agz016 |
ISSN: | 0735-0414 |
Publisher: | Oxford University Press (OUP) |
Start Page: | 196 |
End Page: | 203 |
Journal / Book Title: | Alcohol and Alcoholism |
Volume: | 54 |
Issue: | 3 |
Copyright Statement: | © The Author(s) 2019. Medical Council on Alcohol and Oxford University Press. All rights reserved. This is a pre-copy-editing, author-produced version of an article accepted for publication in Alcohol and Alcoholism following peer review. The definitive publisher-authenticated version is available online at: https://doi.org/10.1093/alcalc/agz016 . |
Keywords: | Science & Technology Life Sciences & Biomedicine Substance Abuse CORTEX MITOCHONDRIAL-FUNCTION ETHANOL-INDUCED HANGOVER FREE-RADICAL PRODUCTION MOTOR-PERFORMANCE BRAIN INTOXICATION ACETATE CONSUMPTION WITHDRAWAL URINE Substance Abuse 1117 Public Health and Health Services 1701 Psychology 1109 Neurosciences |
Publication Status: | Published |
Conference Place: | England |
Online Publication Date: | 2019-03-27 |
Appears in Collections: | Department of Brain Sciences |