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Treatment outcomes in global systematic review and patient meta-analysis of children with extensively drug-resistant tuberculosis
| File | Description | Size | Format | |
|---|---|---|---|---|
 Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis.pdf | Accepted version | 961.79 kB | Adobe PDF | View/Open |
| Title: | Treatment outcomes in global systematic review and patient meta-analysis of children with extensively drug-resistant tuberculosis |
| Authors: | Osman, M Harausz, EP Garcia-Prats, AJ Schaaf, HS Moore, BK Hicks, RM Achar, J Amanullah, F Barry, P Becerra, M Chiotan, DI Drobac, PC Flood, J Furin, J Gegia, M Isaakidis, P Mariandyshev, A Ozere, I Shah, NS Skrahina, A Yablokova, E Seddon, JA Hesseling, AC |
| Item Type: | Journal Article |
| Abstract: | Extensively drug-resistant tuberculosis (XDR TB) has ex-tremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifesta-tions, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 coun-tries. These patients were managed during 1999–2013. For the 37 children, median age was 11 years, 32 (87%) had pulmonary TB, and 29 had a recorded HIV status; 7 (24%) were infected with HIV. Median treatment duration was 7.0 months for the intensive phase and 12.2 months for the continuation phase. Thirty (81%) children had favor-able treatment outcomes. Four (11%) died, 1 (3%) failed treatment, and 2 (5%) did not complete treatment. We found a high proportion of favorable treatment outcomes among children, with mortality rates markedly lower than for adults. Regimens and duration of treatment varied considerably. Evaluation of new regimens in children is required. |
| Issue Date: | 1-Mar-2019 |
| Date of Acceptance: | 1-Mar-2019 |
| URI: | http://hdl.handle.net/10044/1/68648 |
| DOI: | https://dx.doi.org/10.3201/eid2503.180852 |
| ISSN: | 1080-6040 |
| Publisher: | U.S. National Center for Infectious Diseases |
| Start Page: | 441 |
| End Page: | 450 |
| Journal / Book Title: | Emerging Infectious Diseases |
| Volume: | 25 |
| Issue: | 3 |
| Copyright Statement: | Emerging Infectious Diseases is an open access journal in the public domain. All content is freely available without charge to the user or his/her institution. In accordance with the Budapest Open Access Initiative definition of Open Access, users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. Because the journal is in the public domain, its usage policy also conforms to conditions set for by Creative Commons (https://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Science & Technology Life Sciences & Biomedicine Immunology Infectious Diseases MULTIDRUG-RESISTANT MYCOBACTERIUM-TUBERCULOSIS SOUTH-AFRICA HEARING-LOSS DISEASE TB ADOLESCENTS COLLECTION MORTALITY DIAGNOSIS MDR TB XDR TB antimicrobial resistance bacteria children extensively drug-resistant tuberculosis global systematic review meta-analysis mortality multidrug-resistant TB outcomes respiratory infections treatment outcomes tuberculosis tuberculosis and other mycobacteria Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR TB 1108 Medical Microbiology 1117 Public Health And Health Services 1103 Clinical Sciences Microbiology |
| Publication Status: | Published |
| Online Publication Date: | 2019-03-01 |
| Appears in Collections: | Department of Medicine (up to 2019) |