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Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK

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Title: Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK
Authors: Rice, T
Diavatopoulos, D
Smits, G
Van Gageldonk, P
Berbers, G
Van der Klis, F
Vamvakas, G
Donaldson, B
Bouqueau, M
Holder, B
Kampmann, B
Item Type: Journal Article
Abstract: The maternal Tdap (tetanus, diphtheria and acellular pertussis) vaccination program in the UK has successfully reduced cases of pertussis in young infants. In addition to prevention of pertussis cases, it is also important to investigate persistence of maternal antibody during infancy and possible interference of maternal antibodies with infant responses to vaccines. We recruited mother‐infant pairs from vaccinated and unvaccinated pregnancies and measured concentrations of IgG against pertussis toxin (PTx), filamentous hemagglutinin (FHA), pertactin (Prn), diphtheria toxin (DTx), tetanus toxoid (TTx) Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae in mothers and infants at birth, and in infants at 7 weeks and at 5 months. 31 mother‐infant pairs were tested. Tdap‐vaccinated women had significantly higher antibody against Tdap antigens, compared to unvaccinated women (DTx p=0.01; PTx, FHA, Prn and TTx p<0.001). All antibodies were actively transferred to the infants (transfer ratio >1) with higher transfer of DTx (P=0.04) and TTx (P=0.02) antibody in Tdap‐vaccinated pregnancies compared to unvaccinated. Infants from Tdap‐vaccinated pregnancies had significantly elevated antibodies to all antigens at birth (p<0.001) and at 7 weeks (FHA, Prn, TTx p<0.001; DTx p=0.01; PTx p=0.004) compared to infants from unvaccinated pregnancies. Infants from Tdap‐vaccinated and unvaccinated pregnancies had comparable antibody concentrations following primary pertussis immunization (PTx p=0.77; FHA p=0.58; Prn p=0.60; DTx p=0.09; TTx p=0.88). These results support maternal immunisation as a method of protecting vulnerable infants during their first weeks of life.
Issue Date: 24-Jun-2019
Date of Acceptance: 7-Feb-2019
URI: http://hdl.handle.net/10044/1/67450
DOI: https://doi.org/10.1111/cei.13275
ISSN: 1365-2249
Publisher: Wiley
Start Page: 1
End Page: 10
Journal / Book Title: Clinical and Experimental Immunology
Volume: 197
Issue: 1
Copyright Statement: © 2019 The Authors. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council
Medical Research Council (MRC)
NIHR Imperial BRC
NIHR Imperial BRC
Funder's Grant Number: IMPRINT
MC_PC_17221
P72781
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
antibodies
human
reproductive immunology
vaccination
MATERNAL IMMUNIZATION
TDAP IMMUNIZATION
IMMUNE-RESPONSES
DIPHTHERIA
PROTECTION
TETANUS
SAFETY
WOMEN
IMMUNOGENICITY
BIRTH
antibodies
human
reproductive immunology
vaccination
Immunology
1107 Immunology
Publication Status: Published
Online Publication Date: 2019-02-13
Appears in Collections:Department of Infectious Diseases