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Efficient ovalbumin delivery using a novel multifunctional micellar platform for targeted melanoma immunotherapy

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He et al., International Journal of Pharmaceutics, Accepted Manuscript.pdfAccepted version1.57 MBAdobe PDFView/Open
Title: Efficient ovalbumin delivery using a novel multifunctional micellar platform for targeted melanoma immunotherapy
Authors: He, M
Huang, L
Hou, X
Zhong, C
Bachir, ZA
Lan, M
Chen, R
Gao, F
Item Type: Journal Article
Abstract: Cancer immunotherapy is considered to be one of the alternatives to traditional chemotherapy. It's known that foreign antigen, such as ovalbumin (OVA), can label tumor cells, leading to neoantigen recognition by cytotoxic T lymphocytes. Herein, a novel multifunctional micelle coated with PEGylated hyaluronic acid (HA) was prepared through self-assembly and electrostatic interaction. The OVA-loaded micelle with uniform size (132.1 ± 0.2 nm in diameter) exhibited favorable stability and sustained release profiles. The HA-coated micelle could target CD44-overexpressed cells and enhance the cellular uptake of OVA by 11.9 fold compared to free OVA. In vitro studies revealed that the cationic polymer, polyethyleneimine, could facilitate endosomal escape of OVA to label a tumor cell. After treatment with the OVA-loaded micelle, tumor growth in mice was significantly inhibited by 70% compared to the group treated with free OVA. All these results suggest the potential application of the immunotherapeutic micellar platform for melanoma treatment.
Issue Date: 21-Jan-2019
Date of Acceptance: 10-Jan-2019
URI: http://hdl.handle.net/10044/1/67095
DOI: https://dx.doi.org/10.1016/j.ijpharm.2019.01.027
ISSN: 0378-5173
Publisher: Elsevier
Start Page: 1
End Page: 10
Journal / Book Title: International Journal of Pharmaceutics
Volume: 560
Copyright Statement: © 2019 Elsevier B.V. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Immunotherapy
Melanoma
Multifunctional micelle
Ovalbumin
Self-assembly
1115 Pharmacology And Pharmaceutical Sciences
Pharmacology & Pharmacy
Publication Status: Published
Conference Place: Netherlands
Online Publication Date: 2019-01-21
Appears in Collections:Chemical Engineering
Faculty of Engineering