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Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides
File | Description | Size | Format | |
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![]() | Accepted version | 15.68 MB | Adobe PDF | View/Open |
![]() | Supporting information | 8.39 MB | Adobe PDF | View/Open |
Title: | Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides |
Authors: | Tascini, AS Noro, MG Seddon, JM Chen, R Bresme, F |
Item Type: | Journal Article |
Abstract: | The skin surface, our first barrier against the external environment, is covered by the sebum oil, a lipid film composed of sebaceous and epidermal lipids, which is important in the regulation of the hydration level of our skin. Here, we investigate the pathways leading to the transfer of epidermal lipids from the skin lipid bilayer to the sebum. We show that the sebum triglycerides, a major component of sebum, interact strongly with the epidermal lipids and extract them from the bilayer. Using microsecond time scale molecular dynamics simulations, we identify and quantify the free energy associated with the skin lipid extraction process. |
Issue Date: | 21-Jan-2019 |
Date of Acceptance: | 9-Dec-2018 |
URI: | http://hdl.handle.net/10044/1/66704 |
DOI: | https://dx.doi.org/10.1039/c8cp05706k |
ISSN: | 1463-9076 |
Publisher: | Royal Society of Chemistry |
Start Page: | 1471 |
End Page: | 1477 |
Journal / Book Title: | Physical Chemistry Chemical Physics |
Volume: | 21 |
Issue: | 3 |
Copyright Statement: | This journal is © the Owner Societies 2019. |
Sponsor/Funder: | Commission of the European Communities |
Funder's Grant Number: | 608184 |
Keywords: | Science & Technology Physical Sciences Chemistry, Physical Physics, Atomic, Molecular & Chemical Chemistry Physics CHOLESTEROL FLIP-FLOP MOLECULAR-DYNAMICS CERAMIDE BILAYERS DRUG-DELIVERY FATTY-ACIDS MODEL SIMULATION BARRIER WATER NANOPARTICLES Ceramides Cholesterol Epidermis Fatty Acids Lipid Bilayers Molecular Dynamics Simulation Sebum Solid Phase Extraction Thermodynamics Triglycerides 02 Physical Sciences 03 Chemical Sciences Chemical Physics |
Publication Status: | Published |
Conference Place: | England |
Online Publication Date: | 2018-12-17 |
Appears in Collections: | Chemistry Chemical Engineering Faculty of Natural Sciences Faculty of Engineering |