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Individual response variations in scaffold-guided bone regeneration are determined by independent strain- and injury-induced mechanisms

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Title: Individual response variations in scaffold-guided bone regeneration are determined by independent strain- and injury-induced mechanisms
Authors: Reznikov, N
Boughton, O
Ghouse, S
Weston, AE
Collinson, L
Blunn, GW
Jeffers, J
Cobb, J
Stevens, M
Item Type: Journal Article
Abstract: This study explored the regenerative osteogenic response in the distal femur of sheep using scaffolds having stiffness values within, and above and below, the range of trabecular bone apparent modulus. Scaffolds 3D-printed from stiff titanium and compliant polyamide were implanted into a cylindrical metaphyseal defect 15 × 15 mm. After six weeks, bone ingrowth varied between 7 and 21% of the scaffold pore volume and this was generally inversely proportional to scaffold stiffness. The individual reparative response considerably varied among the animals, which could be divided into weak and strong responders. Notably, bone regeneration specifically within the interior of the scaffold was inversely proportional to scaffold stiffness and was strain-driven in strongly-responding animals. Conversely, bone regeneration at the periphery of the defect was injury-driven and equal in all scaffolds and in all strongly- and weakly-responding animals. The observation of the strain-driven response in some, but not all, animals highlights that scaffold compliance is desirable for triggering host bone regeneration, but scaffold permanence is important for the load-bearing, structural role of the bone-replacing device. Indeed, scaffolds may benefit from being nonresorbable and mechanically reliable for those unforeseeable cases of weakly responding recipients.
Issue Date: 1-Feb-2019
Date of Acceptance: 15-Nov-2018
URI: http://hdl.handle.net/10044/1/66420
DOI: 10.1016/j.biomaterials.2018.11.026
ISSN: 0142-9612
Publisher: Elsevier
Start Page: 183
End Page: 194
Journal / Book Title: Biomaterials
Volume: 194
Copyright Statement: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)
Sponsor/Funder: Wellcome Trust
Medical Research Council (MRC)
Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
Royal College Of Surgeons Of England
Royal College of Surgeons of England
Funder's Grant Number: 098411/Z/12/Z
MR/R015651/1
097816/Z/11/B
EP/K027549/1
RDB04 79560
NIHR ACF
WSSU_P63898
Matching orthopaedic surgery to patients' individual bone mechanical properties
Keywords: Science & Technology
Technology
Engineering, Biomedical
Materials Science, Biomaterials
Engineering
Materials Science
Bone regeneration
Scaffold
Ovine model
Stiffness
Strain
microCT
CELL POROUS BIOMATERIALS
SCANNING STRATEGIES
LASER PARAMETERS
CONTACT FORCES
IMAGE-ANALYSIS
TOTAL HIP
WOVEN
REVISION
LAMELLAR
INGROWTH
Bone regeneration
Ovine model
Scaffold
Stiffness
Strain
microCT
Animals
Bone Regeneration
Bone Substitutes
Female
Femur
Hardness
Nylons
Porosity
Printing, Three-Dimensional
Sheep
Tissue Scaffolds
Titanium
Femur
Animals
Sheep
Titanium
Nylons
Bone Substitutes
Bone Regeneration
Hardness
Porosity
Female
Tissue Scaffolds
Printing, Three-Dimensional
Biomedical Engineering
Publication Status: Published
Online Publication Date: 2018-11-23
Appears in Collections:Mechanical Engineering
Materials
Department of Surgery and Cancer
Faculty of Medicine
Faculty of Natural Sciences
Faculty of Engineering