Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)

File Description SizeFormat 
1-s2.0-S0378512218306029-main.pdfPublished version1.45 MBAdobe PDFView/Open
Title: Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)
Authors: Triebner, K
Accordini, S
Calciano, L
Johannessen, A
Benediktsdóttir, B
Bifulco, E
Demoly, P
Dharmage, SC
Franklin, KA
Garcia-Aymerich, J
Gullón Blanco, JA
Heinrich, J
Holm, M
Jarvis, D
Jõgi, R
Lindberg, E
Martínez-Moratalla, J
Muniozguren Agirre, N
Pin, I
Probst-Hensch, N
Raherison, C
Sánchez-Ramos, JL
Schlünssen, V
Svanes, C
Hustad, S
Leynaert, B
Gómez Real, F
Item Type: Journal Article
Abstract: OBJECTIVES: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes. STUDY DESIGN: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. MAIN OUTCOME MEASURES: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). RESULTS: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years. CONCLUSIONS: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.
Issue Date: 1-Feb-2019
Date of Acceptance: 9-Nov-2018
ISSN: 0378-5122
Publisher: Elsevier
Start Page: 29
End Page: 34
Journal / Book Title: Maturitas
Volume: 120
Copyright Statement: © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 633212
Keywords: Hormone replacement therapy (HRT)
Lung function
Reproductive aging
Sex hormones
1103 Clinical Sciences
1114 Paediatrics And Reproductive Medicine
Obstetrics & Reproductive Medicine
Publication Status: Published
Conference Place: Ireland
Online Publication Date: 2018-11-19
Appears in Collections:Infectious Disease Epidemiology
National Heart and Lung Institute
Faculty of Medicine

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons