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Mammalian sugar-binding receptors: known functions and unexplored roles

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Title: Mammalian sugar-binding receptors: known functions and unexplored roles
Authors: Taylor, ME
Drickamer, K
Item Type: Journal Article
Abstract: Mammalian glycan-binding receptors, sometimes known as lectins, interact withglycans, the oligosaccharide portions ofendogenous mammalian glycoproteins and glycolipids as well as sugars on the surfaces of microbes.Thesereceptors guide glycoproteins out of and back into cells, facilitate communication between cells through both adhesion and signaling, and allow the innate immune system to respond quickly to viral, fungal, bacterial,and parasiticpathogens.For many of the roughly one hundred glycan-binding receptors that are known in humans,there aregood descriptions of what types of glycans they bind and how selectivity for these ligands is achievedat the molecular level.In some cases, there is also comprehensive evidencefor the roles thatthe receptors playat the cellular and organismal levels. In addition to highlighting these well-understood paradigms for glycan-binding receptors, this review will suggest where gaps remain in our understandingof the physiological functions that they can serve.
Issue Date: May-2019
Date of Acceptance: 15-Jan-2019
URI: http://hdl.handle.net/10044/1/66105
DOI: 10.1111/febs.14759
https://doi.org/10.1111/febs.14759
ISSN: 1742-464X
Publisher: Wiley
Start Page: 1800
End Page: 1814
Journal / Book Title: FEBS Journal
Volume: 286
Issue: 10
Copyright Statement: © 2019 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: BB/P005659/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
glycan-binding proteins
glycoprotein turnover
innate immunity
intracellular trafficking
lectins
C-TYPE LECTIN
PROTEIN-QUALITY CONTROL
DC-SIGN
STRUCTURAL BASIS
MICE DEFICIENT
P-SELECTIN
MEDIATED REGULATION
LEUKOCYTE ADHESION
GLYCAN ARRAY
LEWIS-X
glycan-binding proteins
glycoprotein turnover
innate immunity
intracellular trafficking
lectins
Biochemistry & Molecular Biology
0601 Biochemistry and Cell Biology
1101 Medical Biochemistry and Metabolomics
0304 Medicinal and Biomolecular Chemistry
Publication Status: Published
Online Publication Date: 2019-01-18
Appears in Collections:Faculty of Natural Sciences