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The bitter side of epigenetics: variability and resistance to chemotherapy

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Title: The bitter side of epigenetics: variability and resistance to chemotherapy
Authors: Hajji, N
García-Domínguez, DJ
Hontecillas-Prieto, L
O'Neill, K
De Álava, E
Syed, N
Item Type: Journal Article
Abstract: One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing number of clinical trial failures appears to be the paucity of accurate, reproducible and robust drug resistance testing methods. Most research assessing the resistance of cancers to chemotherapy has concentrated on genetic-based molecular mechanisms, while the role of epigenetics in drug resistance has been generally overlooked. This is rather surprising given that an increasing body of evidence pointing to the fact that epigenetic mechanism alterations appear to play a pivotal role in cancer initiation, progression and development of chemoresistance. This resulted in a series of clinical trials involving epi-drug as single treatment or combined with cancer conventional drugs. In this review, we provided the main mechanisms by which the epigenetic regulators control the resistance to cancer drugs.
Issue Date: 1-Mar-2021
Date of Acceptance: 2-Jun-2018
URI: http://hdl.handle.net/10044/1/65725
DOI: 10.2217/epi-2017-0112
ISSN: 1750-1911
Publisher: Future Medicine
Start Page: 397
End Page: 403
Journal / Book Title: Epigenomics
Volume: 13
Issue: 5
Copyright Statement: © 2018 Future Medicine Ltd
Sponsor/Funder: Brain Tumour Research Campaign
Barrow Foundation UK
Brain Tumour Research Campaign
Brain Tumour Research
Funder's Grant Number: n/a
Keywords: cancer epigenetics
epigenetic regulations
epigenetic therapies
cancer epigenetics
epigenetic regulations
epigenetic therapies
0604 Genetics
1103 Clinical Sciences
Publication Status: Published
Conference Place: England
Online Publication Date: 2018-06-22
Appears in Collections:Department of Surgery and Cancer
Faculty of Medicine
Department of Brain Sciences