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Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving

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Title: Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving
Authors: Dong, R
Liu, R
Gaffney, P
Schaepertoens, M
Marchetti, P
Williams, C
Chen, R
Livingston, A
Item Type: Journal Article
Abstract: Synthetic chemists have devoted tremendous effort towards the production of precision synthetic polymers with defined sequences and specific functions. However, the creation of a general technology that enables precise control over monomer sequence, with efficient isolation of the target polymers, is highly challenging. Here, we report a robust strategy for the production of sequence-defined synthetic polymers through a combination of liquid-phase synthesis and selective molecular sieving. The polymer is assembled in solution with real-time monitoring to ensure couplings proceed to completion, on a three-armed star-shaped macromolecule to maximize efficiency during the molecular sieving process. This approach is applied to the construction of sequence-defined polyethers, with side-arms at precisely defined locations that can undergo site-selective modification after polymerization. Using this versatile strategy, we have introduced structural and functional diversity into sequence-defined polyethers, unlocking their potential for real-life applications in nanotechnology, healthcare and information storage.
Issue Date: 1-Feb-2019
Date of Acceptance: 10-Oct-2018
URI: http://hdl.handle.net/10044/1/65448
DOI: 10.1038/s41557-018-0169-6
ISSN: 1755-4330
Publisher: Nature Publishing Group
Start Page: 136
End Page: 145
Journal / Book Title: Nature Chemistry
Volume: 11
Copyright Statement: © The Author(s), under exclusive licence to Springer Nature Limited 2019
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/M003949/1
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
ORGANIC-SOLVENT NANOFILTRATION
RADICAL POLYMERIZATION
POLYMERS
COPOLYMERS
SEPARATION
NANOFILMS
OLIGOMERS
STRATEGY
SULFUR
PEG
Organic Chemistry
03 Chemical Sciences
Publication Status: Published
Online Publication Date: 2018-12-03
Appears in Collections:Chemical Engineering
Faculty of Natural Sciences
Faculty of Engineering