Injection moulded microneedle sensor for real-time wireless pH monitoring

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Title: Injection moulded microneedle sensor for real-time wireless pH monitoring
Authors: Mirza, KB
Zuliani, C
Hou, B
Ng, FS
Peters, NS
Toumazou, C
Item Type: Conference Paper
Abstract: This paper describes the development of an array of individually addressable pH sensitive microneedles using injection moulding and their integration within a portable device for real-time wireless recording of pH distributions in biological samples. The fabricated microneedles are subjected to gold patterning followed by electrodeposition of iridium oxide to sensitize them to 0.07 units of pH change. Miniaturised electronics suitable for the sensors readout, analog-to-digital conversion and wireless transmission of the potentiometric data are embodied within the device, enabling it to measure real-time pH of soft biological samples such as muscles. In this paper, real-time recording of the cardiac pH distribution, during ischemia followed by reperfusion cycles in cardiac muscles of male Wistar rats has been demonstrated by using the microneedle array.
Issue Date: 14-Sep-2017
Date of Acceptance: 1-Jan-2017
URI: http://hdl.handle.net/10044/1/65184
ISSN: 1094-687X
Publisher: IEEE
Start Page: 189
End Page: 192
Journal / Book Title: 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Copyright Statement: © 2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 319818
Conference Name: 39th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)
Keywords: Science & Technology
Life Sciences & Biomedicine
Technology
Biophysics
Engineering, Biomedical
Engineering
Animals
Electroplating
Hydrogen-Ion Concentration
Injections
Male
Needles
Potentiometry
Rats
Rats, Wistar
Time Factors
Wireless Technology
Publication Status: Published
Start Date: 2017-07-11
Finish Date: 2017-07-15
Conference Place: Seogwipo, South Korea
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering
National Heart and Lung Institute
Faculty of Medicine



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