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A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes
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A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes.pdf | Published version | 393.7 kB | Adobe PDF | View/Open |
Title: | A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes |
Authors: | Gould, K Cossins, J Bastin, J Brownlee, GG Townsend, A |
Item Type: | Journal Article |
Abstract: | A recombinant vaccinia has been designed to express amino acids 366-379 of influenza nucleoprotein, previously shown to be the minimal epitope recognized by a class I-restricted cytotoxic T cell clone. Target cells infected with the recombinant vaccinia virus expressing this peptide are recognized by CTL as efficiently as target cells expressing the complete nucleoprotein. The results imply the existence of a peptide transport system that constitutively passes the products of degraded proteins from the cytoplasm into a membrane-bound compartment of the cell. |
Issue Date: | 1-Sep-1989 |
Date of Acceptance: | 1-Sep-1989 |
URI: | http://hdl.handle.net/10044/1/65095 |
DOI: | https://dx.doi.org/10.1084/jem.170.3.1051 |
ISSN: | 0022-1007 |
Publisher: | Rockefeller University Press |
Start Page: | 1051 |
End Page: | 1056 |
Journal / Book Title: | Journal of Experimental Medicine |
Volume: | 170 |
Issue: | 3 |
Copyright Statement: | © 1989 Rockefeller University Press. |
Keywords: | Animals Cytoplasm Epitopes Histocompatibility Antigens Class I Influenza A virus Mice Mice, Inbred CBA Nucleoproteins Peptide Fragments RNA-Binding Proteins T-Lymphocytes, Cytotoxic Vaccinia virus Viral Core Proteins Viral Proteins 11 Medical And Health Sciences Immunology |
Publication Status: | Published |
Conference Place: | United States |
Appears in Collections: | Department of Medicine (up to 2019) |