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Update on neutrophil function in severe inflammation

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Title: Update on neutrophil function in severe inflammation
Authors: Mortaz, E
Alipoor, S
Adcock, IM
Mumby, S
Koenderman, L
Item Type: Journal Article
Abstract: Neutrophils are main players in the effector phase of the host defense against micro-organisms and have a major role in the innate immune response. Neutrophils show phenotypic heterogeneity and functional flexibility, which highlight their importance in regulation of immune function. However, neutrophils can play a dual role and besides their antimicrobial function, deregulation of neutrophils and their hyperactivity can lead to tissue damage in severe inflammation or trauma. Neutrophils also have an important role in the modulation of the immune system in response to severe injury and trauma. In this review we will provide an overview of the current understanding of neutrophil subpopulations and their function during and post-infection and discuss the possible mechanisms of immune modulation by neutrophils in severe inflammation.
Issue Date: 2-Oct-2018
Date of Acceptance: 21-Sep-2018
URI: http://hdl.handle.net/10044/1/65001
DOI: https://dx.doi.org/10.3389/fimmu.2018.02171
ISSN: 1664-3224
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Immunology
Volume: 9
Copyright Statement: © 2018 Mortaz, Alipoor, Adcock, Mumby and Koenderman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Wellcome Trust
British Heart Foundation
Dunhill Medical Trust
Funder's Grant Number: 093080/Z/10/Z
PG/14/27/30679
R368/0714
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
neutrophils
infection
CD64
innate immunity
severe inflammation
trauma
EXTRACELLULAR-MATRIX PROTEINS
TUMOR-ASSOCIATED NEUTROPHILS
MULTIPLE ORGAN FAILURE
HUMAN EXPERIMENTAL ENDOTOXEMIA
GR-1(+) MYELOID CELLS
HUMAN LUNG-CANCER
SUPPRESSOR-CELLS
IMMUNE DYSFUNCTION
SERINE PROTEASES
TRAUMA PATIENTS
Publication Status: Published
Article Number: ARTN 2171
Appears in Collections:National Heart and Lung Institute