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Weighing in on mTOR complex 2 signaling: The expanding role in cell metabolism

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Title: Weighing in on mTOR complex 2 signaling: The expanding role in cell metabolism
Authors: Luo, Y
Xu, W
Li, G
Cui, W
Item Type: Journal Article
Abstract: In all eukaryotes, the mechanistic target of rapamycin (mTOR) signaling emerges as a master regulator of homeostasis, which integrates environmental inputs, including nutrients, energy, and growth factors, to regulate many fundamental cellular processes such as cell growth and metabolism. mTOR signaling functions through two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which correspond to two major branches of signal output. While mTORC1 is well characterized for its structure, regulation, and function in the last decade, information of mTORC2 signaling is only rapidly expanding in recent years, from structural biology, signaling network, to functional impact. Here we review the recent advances in many aspects of the mTORC2 signaling, with particular focus on its involvement in the control of cell metabolism and its physiological implications in metabolic diseases and aging.
Issue Date: 30-Oct-2018
Date of Acceptance: 18-Sep-2018
URI: http://hdl.handle.net/10044/1/64951
DOI: https://dx.doi.org/10.1155/2018/7838647
ISSN: 1942-0900
Publisher: Hindawi Publishing Corporation
Journal / Book Title: Oxidative Medicine and Cellular Longevity
Volume: 2018
Copyright Statement: © 2018 Yongting Luo et al. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
PROTEIN-KINASE-C
HYDROPHOBIC MOTIF PHOSPHORYLATION
POSITIVE FEEDBACK LOOP
DE-NOVO LIPOGENESIS
CRYO-EM STRUCTURE
ADIPOSE-TISSUE
LIFE-SPAN
MAMMALIAN TARGET
GLUTAMINE-METABOLISM
INSULIN-RESISTANCE
Publication Status: Published
Article Number: 7838647
Online Publication Date: 2018-10-30
Appears in Collections:Department of Surgery and Cancer