Signaling by small GTPases at cell-cell junctions: protein interactions building control and networks

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Title: Signaling by small GTPases at cell-cell junctions: protein interactions building control and networks
Authors: Braga, V
Item Type: Journal Article
Abstract: A number of interesting reports highlight the intricate network of signaling proteins that coordinate formation and maintenance of cell-cell contacts. We have much yet to learn about how the in vitro binding data is translated into protein association inside the cells and whether such interaction modulates the signaling properties of the protein. What emerges from recent studies is the importance to carefully consider small GTPase activation in the context of where its activation occurs, which upstream regulators are involved in the activation/inactivation cycle and the GTPase interacting partners that determine the intracellular niche and extent of signaling. Data discussed here unravel unparalleled cooperation and coordination of functions among GTPases and their regulators in supporting strong adhesion between cells.
Issue Date: 1-Oct-2018
Date of Acceptance: 7-Aug-2017
URI: http://hdl.handle.net/10044/1/64728
DOI: https://dx.doi.org/10.1101/cshperspect.a028746
ISSN: 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
Journal / Book Title: Cold Spring Harbor perspectives in biology
Volume: 10
Issue: 10
Copyright Statement: Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
NUCLEOTIDE EXCHANGE FACTORS
E-CADHERIN ADHESION
EPITHELIAL-CELLS
ADHERENS JUNCTIONS
P120 CATENIN
MDCK CELLS
ACTIN CYTOSKELETON
CYTOKINETIC FURROW
CONTRACTILE RING
RAC1 ACTIVATION
Cell Biology
Publication Status: Published
Conference Place: United States
Open Access location: http://cshperspectives.cshlp.org/content/early/2017/09/11/cshperspect.a028746.long
Article Number: ARTN a028746
Online Publication Date: 2017-09-11
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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