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A new strategy for intestinal drug delivery via pH-responsive and membrane-active nanogels

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Wang et al, ACS Applied Materials & Interfaces 2018_accepted manuscript.pdfAccepted version698.64 kBAdobe PDFView/Open
Title: A new strategy for intestinal drug delivery via pH-responsive and membrane-active nanogels
Authors: Wang, S
Ha, Y
Huang, X
Chin, B
Sim, W
Chen, R
Item Type: Journal Article
Abstract: Oral administration of hydrophobic and poorly intestinal epithelium-permeable drugs is a significant challenge. Herein, we report a new strategy to overcome this problem by using novel, pH-responsive, and membrane-active nanogels as drug carriers. Prepared by simple physical cross-linking of amphiphilic pseudopeptidic polymers with pH-controlled membrane-activity, the size and hydrophobicity–hydrophilicity balance of the nanogels could be well-tuned. Furthermore, the amphiphilic nanogels could release hydrophobic payloads and destabilize cell membranes at duodenum and jejunum pH 5.0–6.0, which suggests their great potential for intestinal drug delivery.
Issue Date: 31-Oct-2018
Date of Acceptance: 9-Oct-2018
URI: http://hdl.handle.net/10044/1/64691
DOI: https://dx.doi.org/10.1021/acsami.8b15661
ISSN: 1944-8244
Publisher: American Chemical Society
Start Page: 36622
End Page: 36627
Journal / Book Title: ACS Applied Materials and Interfaces
Volume: 10
Issue: 43
Copyright Statement: © 2018 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acsami.8b15661
Keywords: Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
nanogel
pH-responsive
membrane-active
oral delivery
hydrophobic drug
CONTROLLED-RELEASE
CANCER-THERAPY
SOLUBLE DRUGS
NILE RED
FORMULATION
NANOPRECIPITATION
NANOPARTICLES
ABSORPTION
FRONTIERS
CARRIERS
0904 Chemical Engineering
0303 Macromolecular And Materials Chemistry
0306 Physical Chemistry (Incl. Structural)
Publication Status: Published
Online Publication Date: 2018-10-09
Appears in Collections:Chemical Engineering
Faculty of Engineering