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Drug-coated balloon-only percutaneous coronary intervention for the treatment of De novo coronary artery disease: a systematic review

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Title: Drug-coated balloon-only percutaneous coronary intervention for the treatment of De novo coronary artery disease: a systematic review
Authors: Mohiaddin, H
Wong, TDFK
Burke-Gaffney, A
Bogle, RG
Item Type: Journal Article
Abstract: Percutaneous coronary intervention (PCI) with a drug coated balloon (DCB) is a novel treatment which seeks to acutely dilate a coronary stenosis and deliver an anti-proliferative drug to the vessel wall (reducing the risk of re-stenosis), without implanting a drug eluting stent (DES). In this study, we performed a systematic review of stentless DCB-only angioplasty in de novo coronary artery disease. We identified 41 studies examining the effects of DCB-only PCI in a variety of clinical scenarios including small vessels, bifurcations, calcified lesions, and primary PCI. DCB-only PCI appears to be associated with comparable clinical outcomes to DESs and superior angiographic outcomes to plain-old balloon angioplasty. Although current data are promising, there is still a need for further long-term randomized control trial data comparing a DCB-only approach specifically against a second- or third-generation DES. A 4-week period of dual antiplatelet therapy provides a real advantage for the DCB-only PCI approach, which is not possible with most DESs. Since rates of adverse clinical outcomes are very low for all PCI procedures attention should be turned to the development of robust endpoints with which to compare DCB-only PCI approaches to the standard treatment with a DES.
Issue Date: 1-Dec-2018
Date of Acceptance: 4-Sep-2018
URI: http://hdl.handle.net/10044/1/64271
DOI: https://dx.doi.org/10.1007/s40119-018-0121-2
ISSN: 2193-6544
Publisher: Springer Verlag
Start Page: 127
End Page: 149
Journal / Book Title: Cardiology and Therapy
Volume: 7
Issue: 2
Copyright Statement: © 2018 The Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( http://creativecommons.org/licenses/ by-nc/4.0/ ), which permits any noncommer- cial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Coronary artery disease
De novo
Drug-coated balloon
Drug-eluting balloon
Percutaneous coronary intervention
Publication Status: Published
Conference Place: England
Online Publication Date: 2018-10-27
Appears in Collections:National Heart and Lung Institute