109
IRUS Total
Downloads

Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment

File Description SizeFormat 
Manka et al - Author Accepted Manuscript.pdfAccepted version2.21 MBAdobe PDFView/Open
Title: Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment
Authors: Manka, P
Coombes, JD
Boosman, R
Gauthier, K
Papa, S
Syn, WK
Item Type: Journal Article
Abstract: Hepatocellular carcinoma (HCC) commonly arises from a liver damaged by extensive inflammation and fibrosis. Various factors including cytokines, morphogens, and growth factors are involved in the crosstalk between HCC cells and the stromal microenvironment. Increasing our understanding of how stromal components interact with HCC and the signaling pathways involved could help identify new therapeutic and/or chemopreventive targets. It has become increasingly clear that the cross-talk between tumor cells and host stroma plays a key role in modulating tumor growth. Emerging reports suggest a relationship between HCC and thyroid hormone signaling (dysfunction), raising the possibility that perturbed thyroid hormone (TH) regulation influences the cancer microenvironment and cancer phenotype. This review provides an overview of the role of thyroid hormone and its related pathways in HCC and, specifically, its role in regulating the tumor microenvironment.
Issue Date: 10-Apr-2018
Date of Acceptance: 18-Jan-2018
URI: http://hdl.handle.net/10044/1/64269
DOI: https://dx.doi.org/10.1016/j.canlet.2018.01.055
ISSN: 0304-3835
Publisher: Elsevier
Start Page: 175
End Page: 186
Journal / Book Title: Cancer Letters
Volume: 419
Copyright Statement: © 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
Thyroid hormone
Liver cancer
Tumor microenvironment
Liver fibrogenesis
NONALCOHOLIC FATTY LIVER
STELLATE CELL ACTIVATION
CHRONIC HEPATITIS-C
HEPATOCYTE PROLIFERATION
TYPE-3 DEIODINASE
RAT-LIVER
PARTIAL-HEPATECTOMY
BETA-CATENIN
NONTHYROIDAL ILLNESS
DUCTULAR REACTION
1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Online Publication Date: 2018-02-28
Appears in Collections:Department of Surgery and Cancer