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Reward sensitivity predicts dopaminergic response in spatial neglect

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Title: Reward sensitivity predicts dopaminergic response in spatial neglect
Authors: Li, K
Bentley, P
Nair, A
Halse, O
Barker, G
Russell, C
Soto, D
Malhotra, PA
Item Type: Journal Article
Abstract: It has recently been revealed that spatial neglect can be modulated by motivational factors including anticipated monetary reward. A number of dopaminergic agents have been evaluated as treatments for neglect, but the results have been mixed, with no clear anatomical or cognitive predictors of dopaminergic responsiveness. Given that the effects of incentive motivation are mediated by dopaminergic pathways that are variably damaged in stroke, we tested the hypothesis that the modulatory influences of reward and dopaminergic drugs on neglect are themselves related. We employed a single-dose, double-blind, crossover design to compare the effects of Co-careldopa and placebo on a modified visual cancellation task in patients with neglect secondary to right hemisphere stroke. Whilst confirming that reward improved visual search in this group, we showed that dopaminergic stimulation only enhances visual search in the absence of reward. When patients were divided into REWARD-RESPONDERs and REWARD-NON-RESPONDERs, we found an interaction, such that only REWARD-NON-RESPONDERs showed a positive response to reward after receiving Co-careldopa, whereas REWARD-RESPONDERs were not influenced by drug. At a neuroanatomical level, responsiveness to incentive motivation was most associated with intact dorsal striatum. These findings suggest that dopaminergic modulation of neglect follows an ‘inverted U’ function, is dependent on integrity of the reward system, and can be measured as a behavioural response to anticipated reward.
Issue Date: 1-Jan-2020
Date of Acceptance: 3-Sep-2018
URI: http://hdl.handle.net/10044/1/64096
DOI: 10.1016/j.cortex.2018.09.002
ISSN: 0010-9452
Publisher: Elsevier
Start Page: 213
End Page: 224
Journal / Book Title: Cortex
Volume: 122
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: RDA03
Keywords: Science & Technology
Social Sciences
Life Sciences & Biomedicine
Behavioral Sciences
Neurosciences
Psychology, Experimental
Neurosciences & Neurology
Psychology
Attention
Motivation
Neglect
Reward
Dopamine
MEDIAL AGRANULAR CORTEX
UNILATERAL NEGLECT
AGONIST THERAPY
VISUAL NEGLECT
L-DOPA
ATTENTION
APATHY
HEMINEGLECT
STIMULATION
APOMORPHINE
Attention
Dopamine
Motivation
Neglect
Reward
1109 Neurosciences
1702 Cognitive Sciences
1701 Psychology
Experimental Psychology
Publication Status: Published
Online Publication Date: 2018-10-18
Appears in Collections:Department of Brain Sciences



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